Large animal model of left ventricular aneurysm

TL;DR: This review focuses on those methodological and technological aspects considered and developed by the FIBROTARGETS consortium to facilitate the transfer of the new mechanistic knowledge on myocardial fibrosis into potential biomedical applications.

TL;DR: Large animal models recapitulating the clinical HF phenotype in large animal models can allow for the translation of basic science discoveries into clinical therapies and translate basic science to clinical applications have successfully traveled the journey from bench to bedside.

TL;DR: It is found that a difference in circumferential and longitudinal segmental shortening between adjacent and remote noninfarcted myocardium present at 1 week persisted up to 6 months after myocardial infarction, and left ventricular dilatation and eccentric hypertrophy during remodeling are associated with persistent differences in segmental function.

TL;DR: In this paper, the authors used large animal models of congestive heart failure (HF) for the elucidation of biological pathways involved in HF and the development and refinement of HF therapies.

TL;DR: The increasing use of coronary arteriography and other forms of imaging will continue to reveal hitherto undescribed variants, while the study of coronary artery disease will eventually elucidate the natural history of the coronary collateral circulation.