1. What contributions have the authors mentioned in the paper "Lactate administration increases mrna expression of pgc-1α and ucp3 in mouse skeletal muscle" ?
To examine the potential role of lactate as a signaling molecule in skeletal muscle, the authors performed global gene expression analysis of the mouse gastrocnemius muscle, 3 h after lactate administration using the Affymetrix GeneChip system.. Their findings suggest that lactate serves as a signal for upregulating genes related to mitochondrial function.
read more
2. What future works have the authors mentioned in the paper "Lactate administration increases mrna expression of pgc-1α and ucp3 in mouse skeletal muscle" ?
Another group has reported that lactate regulates gene transcription through the inhibition of histone deacetylase ( Latham et al. 2012 ) ; however, further studies are required to clarify the molecular mechanisms.. Their results suggest that lactate, which is well known to be increased during exercise, also acts as a signal for upregulating genes related to mitochondrial function.
read more
