Book Chapter10.1016/S0074-7696(08)61426-6
Kinetoplast DNA in trypanosomid flagellates.
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TL;DR: This chapter discusses the kinetoplast DNA in trypanosomid flagellates and focuses on the general characteristics of minicircle DNA of several species, including Trypanosoma brucei, TrypanOSoma equiperdum, Leishmania tarentolae,Crithidia fasciculata, and Crithidia luciliae.
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Abstract: Publisher Summary This chapter discusses the kinetoplast DNA in trypanosomid flagellates. The chapter reviews the recent developments in the application of recombinant DNA technology to problems of the structure, replication, and transcription of the unusual mitochondrial DNA in the kinetoplastid protozoa known as “kinetoplast DNA.” Kinetoplast DNA is discussed in terms of its two molecular components—minicircles and maxicircles, with an emphasis on species-dependent variations. The chapter focuses on the general characteristics of minicircle DNA of several species, including Trypanosoma brucei, Trypanosoma equiperdum, Leishmania tarentolae, Crithidia fasciculata, and Crithidia luciliae. Unlike most other kinetoplastid species, the kDNA minicircles from T.equiperdum are homogeneous in base sequence. The minicircles in the Leishmania are the smallest reported to date. L .tarentolae minicircles are about 870 bp in size and show extensive sequence heterogeneity by restriction enzyme analysis. The minicircles in the Leishmania are the smallest reported to date. L.tarentolae minicircles are about 870 bp in size and show extensive sequence heterogeneity by restriction enzyme analysis. The maxicircle component of the kinetoplast DNA appears to represent the homolog of the informational mitochondria1 DNA found in other eukaryotic cells.
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Citations
Kinetoplast DNA minicircles of Leishmania donovani express a protein product.
Neeloo Singh,Anil K. Rastogi +1 more
TL;DR: In this article, an open reading frame present in the variable region in one of the minicircle sequence classes of a human pathogenic strain of Leishmania donovani (MHOM/IN/90/RMRI 68) was found.
9
Centromere, kinetochore, kinochore, kinetosome, kinosome, kinetomere, kinomere, kinetocentre, kinocentre: history, etymology and intepretation
TL;DR: The author emphasizes the linguistic difference between the prefixes kino– and kineto– in relation to the compound terms which refer to chromosome movement and to mitosis, as they are currently described for the cells of higher eukaryotes.
9
Identification of a novel large extrachromosomal DNA (LED) in the Trypanosomatidae.
Wilma Wagner,Magdalene So +1 more
TL;DR: The presence of LED in four evolutionarily distant trypanosomatid species suggests that it plays an important rote in the biology of these parasites.
9
Regulation of mitochondrial gene expression in Trypanosoma brucei.
TL;DR: The results suggest the presence of post‐transcriptional mechanisms that regulate the expression of mitochondrial genes during the life cycle of T. brucei.
8
Genetic polymorphism of Leishmania species using kinetoplast DNA restriction fragment length polymorphism and cDNA probe of Leishmania donovani.
TL;DR: The present study indicates that the cDNA probe B2a1 can be used as an important adjunct to kDNA restriction analysis for the characterization of Leishmania species.
7
References
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Hen-Ming Wu,Donald M. Crothers +1 more
TL;DR: The bending locus of trypanosome kinetoplast DNA, identified by gel electrophoresis, has tracts of a simple repeat sequence symmetrically distributed about it, with a repeat interval of 10 base pairs.
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Origins of prokaryotes, eukaryotes, mitochondria, and chloroplasts
TL;DR: The symbiotic theory of cellular evolution is considered the most probable because it holds that organelles, e.g., mitochondria and chloroplasts invaded larger bodies, and combined functions to form eucaryotic cells.
573
Strains and clones of Trypanosoma cruzi can be characterized by pattern of restriction endonuclease products of kinetoplast DNA minicircles.
TL;DR: It is shown that, from a given T. cruzi strain, clones with different biological properties can be isolated and identified by their restriction patterns.
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