Journal Article10.1016/0006-2952(94)90077-9
Kinetic studies with the non-nucleoside human immunodeficiency virus type-1 reverse transcriptase inhibitor U-90152E
Irene W. Althaus,James J. Chou,A. J. Gonzales,Martin R. Deibel,Kuo-Chen Chou,F. J. Kezdy,Donna Lee Romero,Richard C. Thomas,Paul A. Aristoff,W G Tarpley +9 more
68
TL;DR: Kinetic studies indicate that U-90152E acts exclusively as a mixed inhibitor with respect to the template: primer and dNTP binding sites for both the RNA- and DNA-directed DNA polymerase domains of the enzyme.
read more
About: This article is published in Biochemical Pharmacology. The article was published on 01 Jun 1994. The article focuses on the topics: Non-competitive inhibition & Polymerase.
read more
Chat with Paper
AI Agents for this Paper
Find similar papers on Google Scholar, PubMed and Arxiv
Write a critical review of this paper
Analyze citations of this paper to find unaddressed research gaps
Citations
Polyprotein cleavage mechanism of SARS CoV Mpro and chemical modification of the octapeptide.
Qi Shi Du,Shuqing Wang,Yu Zhu,Dong-Qing Wei,Dong-Qing Wei,Hong Guo,Suzanne Sirois,Kuo-Chen Chou,Kuo-Chen Chou +8 more
TL;DR: The octapeptide (AVLQSGFR) is found to be a “distorted key” and a potential starting system for the design of anti SARS drugs, and the scissile peptide bond between Gln and Ser is finding to be solidified through “hybrid peptide bonded” by changing the carbonyl group CO of Gln to CH2 or CF2.
89
Progresses in Predicting Post-translational Modification
TL;DR: This review is focused on those prediction methods that have the following two features: their cornerstones have been based on Pseudo Amino Acid Composition or Pseudo K-tuple Nucleotide Composition, and hence the prediction quality is generally higher than most of the other PTM prediction methods.
86
A Two-Level Computation Model Based on Deep Learning Algorithm for Identification of piRNA and Their Functions via Chou’s 5-Steps Rule
TL;DR: A two level computational model based on deep neural network (DNN) that automatically extract informative features from RNA sequences using standard learning methods that performed better than the existing predictors with accuracy level 91.81% and 84.52% in the first level and in the second level respectively.
85
The benzylthio-pyrimidine U-31,355, a potent inhibitor of HIV-1 reverse transcriptase.
Irene W. Althaus,Kuo-Chen Chou,Richelle J. Lemay,Kellie M. Franks,Martin R. Deibel,Ferenc J. Kezdy,Lionel Resnick,Mariano Busso,Antero G. So,Kathleen M. Downey,Donna L. Romero,Richard C. Thomas,Paul A. Aristoff,W. Gary Tarpley,Fritz Reusser +14 more
TL;DR: Kinetic studies indicate that U-31,355 acts as a mixed inhibitor with respect to the template:primer and dNTP binding sites associated with the RNA-directed DNA polymerase domain of the enzyme.
81
Prediction of HIV-1 and HIV-2 proteins by using Chou’s pseudo amino acid compositions and different classifiers
TL;DR: The results of the jackknife test indicated that the highest prediction accuracy and CC values were obtained by the SVM and MP were 0.9909 and 0.9763, respectively, indicating that the classifiers presented in this study were suitable for predicting two groups of HIV proteins.
References
Inhibition of HIV-1 Replication by a Nonnucleoside Reverse Transcriptase Inhibitor
Vincent J. Merluzzi,K. D. Hargrave,M. Labadia,Grozinger Karl G,Mark T. Skoog,Joe C. Wu,Cheng-Kon Shih,K. Eckner,S. Hattox,Julian Adams +9 more
TL;DR: Dipyridodiazepinones inhibition of HIV-1 replication in vitro as demonstrated by in situ hybridization, inhibition of protein p24 production, and the lack of syncytia formation in cultured human T cell lines and freshly isolated human peripheral blood lymphocytes.
779
Sulfated polysaccharides are potent and selective inhibitors of various enveloped viruses, including herpes simplex virus, cytomegalovirus, vesicular stomatitis virus, and human immunodeficiency virus.
TL;DR: Several sulfated polysaccharides proved to be potent inhibitors for herpes simplex virus, human cytomegalovirus, vesicular stomatitis virus, Sindbis virus, and human immunodeficiency virus.
555
Nonnucleoside reverse transcriptase inhibitors that potently and specifically block human immunodeficiency virus type 1 replication
Donna Lee Romero,Mariano Busso,C.‐K. Tan,Fritz Reusser,J R Palmer,S M Poppe,Paul A. Aristoff,Kathleen M. Downey,Antero G. So,Lionel Resnick +9 more
TL;DR: Evaluation of a BHAP in HIV-1-infected SCID-hu mice (severe combined immunodeficient mice implanted with human fetal lymph node) showed that the compound could block HIV- 1 replication in vivo.
255
Dextran sulfate and other polyanionic anti-HIV compounds specifically interact with the viral gp120 glycoprotein expressed by T-cells persistently infected with HIV-1.
TL;DR: The inhibitory effect of dextran sulfate and its congeners on the interaction of the HIV gp120 with the cellular CD4 receptor can be ascribed to a specific binding ("shielding") of gp120.
220
Applications of graph theory to enzyme kinetics and protein folding kinetics: Steady and non-steady-state systems
TL;DR: Four graphic rules are summarized, which can be used to deal with protein folding systems as well as enzyme-catalyzed systems and have the following advantages: Complicated and tedious calculations can be greatly simplified and a lot of wasted labor can be turned away.
216