Journal Article10.1007/S11814-017-0147-5
Kinetic and thermodynamic characteristics of crystallization of vancomycin
Geon Soo Ha,Jin-Hyun Kim +1 more
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TL;DR: In this paper, the effect of the major process parameters (crystallization temperature and time) on the efficiency of the vancomycin crystallization process and conducted a kinetic and thermodynamic analysis.
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Abstract: We investigated the effect of the major process parameters (crystallization temperature and time) on the efficiency of the vancomycin crystallization process and conducted a kinetic and thermodynamic analysis. The most clear and uniform vancomycin crystals with the highest yield (~98%) were obtained at the optimum crystallization temperature (283 K) and time (1,440 min). The electron microscope, SEM, and XRD analyses showed that intact crystalline vancomycin was obtained when using a crystallization temperature of 283, 288, and 293 K. The kinetic analysis results revealed that the Johnson-Mehl-Avrami-Kolmogorov (JMAK) model was suitable with a high value for r2 (>0.9561) and low value for RMSD (<0.0170). Finally, from the thermodynamic analysis the Gibb’s free energy change (ΔG0), entropy change (ΔS0), and enthalpy change (ΔH0) were all negative, indicating that the crystallization process was spontaneous, irreversible, and exothermic.
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TL;DR: In this article , the authors compared antisolvent and salting-out precipitations in their precipitation efficiency and product qualities for bioactive peptides, and showed that heavy precipitates composed of nanoparticles were the predominant products of antisolent precipitation, in contrast to crystalline microparticles produced by salting out.
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Development of Drying Process for Removal of Residual Solvent from Crystalline Vancomycin and Kinetic and Thermodynamic Analysis Thereof
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TL;DR: In this article, a microwave-assisted drying method using ethanol pretreatment was developed that can effectively remove residual solvent from crystalline vancomycin, and the experimental data were fitted to the Newton, Page, Modified Page, Henderson and Pabis, and Geometric models.
2
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