Kidney disease in lupus is not always 'lupus nephritis'
TL;DR: In lupus erythematosus, elevated serum creatinine levels and urinary abnormalities implicate a kidney disorder, which may not always be l upus nephritis as defined by the current classification of the International Society of Nephrology/Renal Pathology Society.
read more
Abstract: In lupus erythematosus, elevated serum creatinine levels and urinary abnormalities implicate a kidney disorder, which may not always be lupus nephritis as defined by the current classification of the International Society of Nephrology/Renal Pathology Society. The signs of renal dysfunction may be caused by lupusunrelated renal injury such as drug toxicity or infection or by lupus-associated mechanisms that are not part of the classification, such as minimal change nephrotic syndrome or thrombotic microangiopathy. The latter seems to complicate lupus nephritis more frequently than previously thought. An unbiased assessment of kidney disease in lupus requires a kidney (re-)biopsy to define the appropriate management.
read more
Chat with Paper
AI Agents for this Paper
Find similar papers on Google Scholar, PubMed and Arxiv
Write a critical review of this paper
Analyze citations of this paper to find unaddressed research gaps
Citations
A pathophysiology-based approach to the diagnosis and treatment of lupus nephritis.
TL;DR: An update on the pathophysiology of lupus and its related kidney disease is provided, areas of controversy in disease management are considered, and the unmet needs of l upus nephritis are discussed and how to address these needs are discussed.
99
The lupus nephritis management renaissance
01 Feb 2022
TL;DR: In this article , the authors reviewed new developments in these areas of lupus nephritis and put them into perspective for disease management now and in the future, and discussed how molecular technologies can be applied to interrogate biopsies and how such data can impact management, and how to incorporate LN biomarkers into management paradigms.
26
Curcumin attenuates autoimmunity and renal injury in an experimental model of systemic lupus erythematosus.
TL;DR: It is suggested that curcumin modulates autoimmune activity and may lessen renal injury in female mice with SLE and is also used in Eastern medicine for its anti‐inflammatory and antioxidant properties.
17
Lupus Nephritis in Children: Novel Perspectives
Marco Pennesi,Simone Benvenuto +1 more
TL;DR: An overview of the novel perspectives on the pathogenetic mechanisms, histopathological classification, therapeutic approach, novel biomarkers, and follow-up targets in children and adolescents with lupus nephritis are provided.
15
Clinical measurement of lupus nephritis activity is inferior to biomarker-based activity assessment using the renal activity index for lupus nephritis in childhood-onset systemic lupus erythematosus
Najla Aljaberi,Scott E. Wenderfer,Arjun Mathur,Tingting Qiu,Steffy Jose,Angela Merritt,James Rose,Prasad Devarajan,Bin Huang,Hermine I. Brunner +9 more
TL;DR: The RAIL may constitute important auxiliary tool for the surveillance of LN in a clinical setting and assist with the decision to obtain a kidney biopsy in children and adolescents with SLE.
References
Systemic lupus erythematosus
Jessica J Manson,Anisur Rahman +1 more
TL;DR: Systemic lupus erythematosus is a relapsing and remitting disease, and treatment aims are threefold: managing acute periods of potentially life-threatening ill health, minimizing the risk of flares during periods of relative stability, and controlling the less life- threatening, but often incapacitating day to day symptoms.
•Book
Systemic Lupus Erythematosus
George C. Tsokos
- 01 Jun 1976
TL;DR: Contributions are gathered from physicians and researchers from North America, South America, Europe, and Asia that highlight several important and/or novel aspects of the molecular pathogenesis, clinical organ involvement, and experimental therapies in this prototypical systemic autoimmune disease.
The Classification of Glomerulonephritis in Systemic Lupus Erythematosus Revisited
Jan J. Weening,Vivette D. D'Agati,Melvin M. Schwartz,Surya V. Seshan,Charles E. Alpers,Gerald B. Appel,James E. Balow,Jan A. Bruijn,Terence Cook,Franco Ferrario,Agnes B. Fogo,Ellen M. Ginzler,Lee A. Hebert,Gary Hill,Prue Hill,J. Charles Jennette,Norella C T Kong,Philippe Lesavre,Michael D. Lockshin,Lai-Meng Looi,Hirofumi Makino,Luiz Antonio Ribeiro de Moura,Michio Nagata +22 more
TL;DR: The main advantages of the current revised classification is that it provides a clear and unequivocal description of the various lesions and classes of lupus nephritis, allowing a better standardization and lending a basis for further clinicopathologic studies.
The classification of glomerulonephritis in systemic lupus erythematosus revisited
Jan J. Weening,Vivette D. D'Agati,Melvin M. Schwartz,Surya V. Seshan,Charles E. Alpers,Gerald B. Appel,James E. Balow,Jan A. Bruijn,Terence Cook,Franco Ferrario,Agnes B. Fogo,Ellen M. Ginzler,Lee A. Hebert,Gary Hill,Prue Hill,J. Charles Jennette,Norella C T Kong,Philippe Lesavre,Michael D. Lockshin,Lai-Meng Looi,Hirofumi Makino,Luiz Antonio Ribeiro de Moura,Michio Nagata +22 more
TL;DR: The main advantages of the current revised classification is that it provides a clear and unequivocal description of the various lesions and classes of lupus nephritis, allowing a better standardization and lending a basis for further clinicopathologic studies.
1.8K