Open Access
KDIGO Clinical Practice Guideline for Glomerulonephritis
Kai-Uwe Eckardt,Bertram L. Kasiske +1 more
- 01 Jan 2012
Vol. 2, Iss: 2
987
TL;DR: This chapter discusses general principles in the management of glomerular disease, as well as methods for guideline development and examples of successful implementation of these principles.
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Abstract: 142 Summary of Recommendation Statements 143 Chapter 1: Introduction 154 Chapter 2: General principles in the management of glomerular disease 156 Chapter 3: Steroid-sensitive nephrotic syndrome in children 163 Chapter 4: Steroid-resistant nephrotic syndrome in children 172 Chapter 5: Minimal-change disease in adults 177 Chapter 6: Idiopathic focal segmental glomerulosclerosis in adults 181 Chapter 7: Idiopathic membranous nephropathy 186 Chapter 8: Idiopathic membranoproliferative glomerulonephritis 198 Chapter 9: Infection-related glomerulonephritis 200 Chapter 10: Immunoglobulin A nephropathy 209 Chapter 11: Henoch-Schönlein purpura nephritis 218 Chapter 12: Lupus nephritis 221 Chapter 13: Pauci-immune focal and segmental necrotizing glomerulonephritis 233 Chapter 14: Anti-glomerular basement membrane antibody glomerulonephritis 240 Methods for guideline development 243 Biographic and Disclosure Information 252
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Citations
The Treatment of Minimal Change Disease in Adults
Jonathan Hogan,Jai Radhakrishnan +1 more
TL;DR: MCD in adults is reviewed with particular focus on the evidence for immunosuppressive therapy in patients with recurrent relapses, and some patients become steroid-resistant (SR), steroid-dependent (SD), or frequently relapsing (FR).
151
After ten years of follow-up, no difference between supportive care plus immunosuppression and supportive care alone in IgA nephropathy.
Thomas Rauen,Stephanie Wied,Christina Fitzner,Frank Eitner,Frank Eitner,Claudia Sommerer,Martin Zeier,Britta Otte,Ulf Panzer,Klemens Budde,Urs Benck,Peter R. Mertens,Uwe Kuhlmann,Oliver Witzke,Oliver Gross,Volker Vielhauer,Johannes F.E. Mann,Ralf-Dieter Hilgers,Jürgen Floege,Marcus J. Moeller,Horst Weihprecht,Harm Peters,Saban Elitok,Markus Bieringer,Ralf Schindler,Ulrich Frei,Sima Canaan–Kühl,Christiane M. Erley,Karsten Schlieps,Frans Zandvoort,Bernd Hohenstein,Christian Hugo,Catrin Palm,Karl Hilgers,Hermann Haller,Anna Bertram,Gunter Wolf,Martin Busch,Thomas Rath,Stephan Ziefle,Thomas Benzing,Franziska Grundmann,Stefan Westphalen,Uwe Gottmann,Michael Fischereder,Oliver Sarkar,Marianna Stefanidou,Hermann Pavenstädt,Bernhard Banas,Alexander Boeger,Nils Heyne,Ferruh Artunc,Helmut Reichel,Thomas Mettang,Christoph Wanner,Thomas Metzger +55 more
TL;DR: Over a follow-up of up to ten years and using an adapted primary endpoint, it was failed to detect differences in key clinical outcomes in IgAN patients randomized to receive added immunosuppression on top of supportive care versus supportive care alone.
150
Effectiveness of mycophenolate mofetil in C3 glomerulonephritis
Cristina Rabasco,Teresa Cavero,Elena Román,Jorge Rojas-Rivera,Teresa Olea,Mario Espinosa,Virginia Cabello,Gema Fernández-Juárez,F. González,Ana Ávila,José Baltar,Montserrat Diaz,Raquel Alegre,Sandra Elías,Monserrat Antón,Miguel Angel Frutos,Alfonso Pobes,Miguel Blasco,Francisco Martín,Carmen Bernis,Manuel Macías,Sergio Barroso,Alberto de Lorenzo,Gema Ariceta,Manuel López-Mendoza,Begoña Rivas,Katia López-Revuelta,José María Campistol,Santiago Mendizábal,Santiago Rodríguez de Córdoba,Manuel Praga +30 more
TL;DR: Renal survival and the number of patients achieving clinical remission were significantly higher in patients treating with corticosteroids plus mycophenolate mofetil as compared with patients treated with other immunosuppressive regimens and untreated patients, respectively.
150
Non‐corticosteroid immunosuppressive medications for steroid‐sensitive nephrotic syndrome in children
Nicholas Larkins,Isaac Desheng Liu,Narelle S Willis,Jonathan C. Craig,Elisabeth M Hodson,Elisabeth M Hodson +5 more
TL;DR: Evaluating the benefits and harms of non-corticosteroid immunosuppressive medications in relapsing SSNS in children found cyclosporin was more effective than mycophenolate mofetil in maintaining remission and levamisole was not sustained once treatment was stopped.
146
A prospective observational cohort study highlights kidney biopsy findings of lupus nephritis patients in remission who flare following withdrawal of maintenance therapy.
Marcelo De Rosa,Francisco Azzato,Jorge E. Toblli,Graciela De Rosa,Federico Fuentes,Haikady N. Nagaraja,Ryan Nash,Brad H. Rovin +7 more
TL;DR: A repeat kidney biopsy may be useful in managing maintenance immunosuppression in LN, and patients in histologic remission may be candidates for withdrawal of therapy.
143
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