Kainate Receptors Act as Conditional Amplifiers of Spike Transmission at Hippocampal Mossy Fiber Synapses
TL;DR: It is shown that presynaptic and postsynaptic KARs concur to amplify unitary Mf synaptic inputs to trigger spike discharge within a wide range of frequencies (from 1 to 50 Hz), contributing largely to the “conditional detonator” function of Mf synapses.
read more
Abstract: Hippocampal mossy fiber (Mf) synapses are viewed as conditional detonators, assisting CA3 cells in complex network functions. By analyzing mice deficient for GluK2 (GluR6), GluK3 (GluR7) and GluK5 (KA2) genes we show that kainate receptors (KARs) play a crucial role in the control of synaptic integration and spike transmission efficacy at Mf synapses. We dissected out the role of the different KAR functions at Mf synapses and we show that presynaptic and postsynaptic KARs concur to amplify unitary Mf synaptic inputs to trigger spike discharge within a wide range of frequencies (from 1 to 50 Hz). Moreover, KARs strongly favor spike transmission in response to patterns of presynaptic activity mimicking in vivo dentate granule cell activity. By amplifying spike transmission, KARs also facilitate the induction of associative long-term potentiation in CA3. Hence the actions of KARs as amplifiers of spike transmission contribute largely to the "conditional detonator" function of Mf synapses and are likely important for spatial information processing.
read more
Chat with Paper
AI Agents for this Paper
Find similar papers on Google Scholar, PubMed and Arxiv
Write a critical review of this paper
Analyze citations of this paper to find unaddressed research gaps
Citations
Glutamate Receptor Ion Channels: Structure, Regulation, and Function
Stephen F. Traynelis,Lonnie P. Wollmuth,Chris J. McBain,Frank S. Menniti,Katie M. Vance,Kevin K. Ogden,Kasper B. Hansen,Hongjie Yuan,Scott J. Myers,Raymond Dingledine +9 more
TL;DR: This review discusses International Union of Basic and Clinical Pharmacology glutamate receptor nomenclature, structure, assembly, accessory subunits, interacting proteins, gene expression and translation, post-translational modifications, agonist and antagonist pharmacology, allosteric modulation, mechanisms of gating and permeation, roles in normal physiological function, as well as the potential therapeutic use of pharmacological agents acting at glutamate receptors.
Kainate receptors coming of age: milestones of two decades of research
TL;DR: This review pieces together highlights from the two decades of research subsequent to the cloning of the first subunit, and provides an overview of the current understanding of the role of KARs in the CNS and their potential importance to neurological and neuropsychiatric disorders.
307
Reversal of hippocampal neuronal maturation by serotonergic antidepressants.
Katsunori Kobayashi,Yumiko Ikeda,Atsushi Sakai,Nobuyuki Yamasaki,Eisuke Haneda,Tsuyoshi Miyakawa,Hidenori Suzuki +6 more
TL;DR: The results suggest that serotonergic antidepressants can reverse the established state of neuronal maturation in the adult hippocampus, and up-regulation of 5-HT4 receptor-mediated signaling may play a critical role in this distinct action of antidepressants.
207
Operation and plasticity of hippocampal CA3 circuits: implications for memory encoding
TL;DR: New insight is gained into the operation and plasticity of CA3 circuits, including the identification of novel forms of synaptic plasticity and their underlying mechanisms, and structural plasticity in the GABAergic control ofCA3 circuits.
201
Distinct functions of kainate receptors in the brain are determined by the auxiliary subunit Neto1
Christoph Straub,David L Hunt,Miwako Yamasaki,Kwang S. Kim,Masahiko Watanabe,Pablo E. Castillo,Susumu Tomita +6 more
TL;DR: It is found that both the high-affinity binding pattern in the mouse brain and the channel properties of native KARs are determined by the KAR auxiliary subunit Neto1, which can control synaptic temporal summation, spike generation and fidelity.
134
References
Spatial selectivity of unit activity in the hippocampal granular layer.
TL;DR: Observations indicate that granule cells of the fascia dentata provide their CA3 targets with a high degree of spatial information, in the form of a sparsely coded, distributed representation.
822
GABAergic Cells Are the Major Postsynaptic Targets of Mossy Fibers in the Rat Hippocampus
TL;DR: Granule cells developed distinct types of terminals to affect interneurons and pyramidal cells and they innervated more inhibitory than excitatory cells, which may explain the physiological observations that increased activity of granule cells suppresses the overall excitability of the CA3 recurrent system.
818
Quantal components of unitary EPSCs at the mossy fibre synapse on CA3 pyramidal cells of rat hippocampus
TL;DR: Five of nine EPSC peak amplitude distributions were judged to be quantal, suggesting that extracellular stimulation was focal, and that the stimulus‐evoked EPSCs were unitary.
771
Synaptic plasticity at hippocampal mossy fibre synapses
Roger A. Nicoll,Dietmar Schmitz +1 more
TL;DR: Recent work from several laboratories on the various forms of synaptic plasticity at hippocampal mossy fibre synapses conclude that these contacts have just begun to reveal their many secrets.
675
NMDA receptors, place cells and hippocampal spatial memory.
Kazu Nakazawa,Thomas J. McHugh,Thomas J. McHugh,Matthew A. Wilson,Susumu Tonegawa,Susumu Tonegawa +5 more
TL;DR: The data that have emerged from in vivo hippocampal recording studies that indicate that the activity of hippocampal place cells during behaviour is an expression of a memory trace are discussed.