Journal Article10.1055/A-1497-9777
Joint Effect of Multiple Prothrombotic Genotypes and Obesity on the Risk of Incident Venous Thromboembolism.
Tobias Frischmuth,Kristian Hindberg,Maiken Elvestad Gabrielsen,Ben Michael Brumpton,Kristian Hveem,Sigrid Kufaas Brækkan,Sigrid Kufaas Brækkan,John-Bjarne Hansen,John-Bjarne Hansen,Vânia M. Morelli +9 more
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TL;DR: In this paper, the authors investigated the joint effect of obesity and a genetic risk score composed of established prothrombotic single nucleotide polymorphisms (SNPs) on venous thromboembolism (VTE) risk using a population-based case-cohort.
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Abstract: BACKGROUND The impact of the combination of obesity and multiple prothrombotic genotypes on venous thromboembolism (VTE) risk remains unclear. OBJECTIVE To investigate the joint effect of obesity and a genetic risk score (GRS) composed of established prothrombotic single nucleotide polymorphisms (SNPs) on VTE risk using a population-based case-cohort. METHODS Cases with incident VTE (n = 1,470) and a subcohort (n = 12,826) were derived from the Tromso Study (1994-2012) and the Trondelag Health Study (HUNT) (1995-2008). Participants were genotyped for ABO (rs8176719), F5 (rs6025), F2 (rs1799963), FGG (rs2066865), and F11 (rs2036914) SNPs. Age- and sex-adjusted hazard ratios (HRs) were estimated according to body mass index (BMI) categories and number of risk alleles for individual SNPs and the GRS (0-1, 2, 3, ≥4 alleles). RESULTS The combination of obesity (BMI ≥ 30kg/m2) and risk alleles, either as individual SNPs or as a GRS, had an additive effect on VTE risk (i.e., no biological interaction). Obese subjects who were carriers of ≥4 risk alleles had a 2.85-fold (95% confidence interval [CI]: 2.05-3.96) increased risk of overall VTE compared with those with BMI <25 kg/m2 and 0 to 1 risk allele. However, in subgroups, the combination of obesity and ≥4 risk alleles was more pronounced for deep vein thrombosis (DVT) (HR: 3.20; 95% CI: 2.09-4.90) and unprovoked VTE (HR: 3.82; 95% CI: 2.25-6.47), suggesting a supra-additive effect. CONCLUSION Our findings indicate that the combination of obesity and GRS has an additive effect on the risk of overall VTE. However, it may have a supra-additive effect on the risk of DVT and unprovoked VTE.
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Citations
Country-Level Factors Dynamics and ABO/Rh Blood Groups Contribution To COVID-19 Mortality
Alfonso Monaco,Ester Pantaleo,Nicola Amoroso,Loredana Bellantuono,Alessandro Stella,Roberto Bellotti +5 more
- 14 Jun 2021
TL;DR: Using a machine learning approach, it is found that the “B+” blood group frequency is an important factor at all stages of the pandemic.
The Interplay Between Obesity and Venous Thromboembolism: From Molecular Aspects to Clinical Issue
Patrycja Sandra Zawadzka,Anna M Imiela,Piotr Pruszczyk,Patrycja Sandra Zawadzka,Anna M Imiela,Piotr Pruszczyk +5 more
Abstract: This review examines the intricate relationship between obesity and venous thromboembolism (VTE), highlighting the underlying pathophysiological mechanisms and clinical implications. Obesity is an established independent risk factor for VTE, which includes deep vein thrombosis (DVT) and pulmonary embolism (PE). The risk of VTE escalates with increasing body mass index (BMI) and is particularly associated with abdominal adiposity. Dysfunctional adipose tissue (AT) in obesity promotes a pro-thrombotic state through chronic low-grade inflammation and impaired fibrinolysis. This inflammation is driven by stress within hypertrophied adipocytes, which leads to localized hypoxia, cellular dysfunction, and ultimately, cell death. This inflammation is driven by adipocyte stress and the infiltration of immune cells. The adipokine leptin exemplifies the complex link between obesity and VTE. While leptin has pro-thrombotic effects, low leptin levels are paradoxically associated with an increased morbidity and mortality in patients with acute PE, a phenomenon termed the “obesity paradox”. Furthermore, metabolic syndrome significantly increases the risk of recurrent VTE, with the risk growing with each additional metabolic component. Ultimately, a deeper understanding of the molecular and cellular links between obesity and VTE is essential for developing targeted strategies to reduce risk and improve outcomes in this vulnerable population.
The interaction effect of transfusion history and previous stroke history on the risk of venous thromboembolism in stroke patients: a prospective cohort study
Changqing Sun,Rongrong Wang,Lianke Wang,Panpan Wang,Ying Qin,Qianyu Zhou,Yuanli Guo,Min Zhao,Wen He,Qiang Zhang +9 more
TL;DR: Wang et al. as mentioned in this paper explored whether the combination of transfusion history and previous stroke history increases the risk of venous thromboembolism (VTE) among Chinese stroke patients.
Additional file 1 of The interaction effect of transfusion history and previous stroke history on the risk of venous thromboembolism in stroke patients: a prospective cohort study
Sun Chang-qing,Wang Rongrong,Wang Lianke,Wang Panpan,Qin Ying,Zhou, Qianyu,Guo Yuanli,Zhao, Mingyang,He Wen-Qian,Hu Bo,Zhang Peijia,Wu TianTian,Wang Yu,Zhang Qiang +13 more
- 13 Aug 2024
Abstract: Additional file 1: Figure S1. OR of VTE from different exposure in patients with NIHSS score > 5 points.
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