Its written all over your face: The molecular and physiological consequences of aging skin.

TL;DR: The results demonstrate that the first skin-specific second-generation epigenetic age clock, VisAgeX, specifically predicting visual age progression, not only captures known biological pathways associated with skin aging, but also adds novel pathways associated with skin aging.

TL;DR: According to these results, the co-administration of VA and FA effectively mitigated the process of UVB-induced photoaging by reducing oxidative stress injury, inflammation responses, and regulating cell growth.

TL;DR: This review synthesizes recent knowledge on skin aging, highlighting key factors driving senescence, including mitochondrial ROS overproduction, protein glycation, and telomere shortening, and discusses biomarkers for assessing skin aging, such as SA-β-gal and AGEs fluorescence.

TL;DR: The aging face phenomenon is a complex process involving changes in various facial structures and tissues. It is important to understand the evolution in this field due to increased life expectancy. The manuscript aims to review the main achievements and explore novel research avenues in molecular biology and confocal immunofluorescence.

TL;DR: It is demonstrated that HFSCs utilize glycolytic metabolism and produce significantly more lactate than other cells in the epidermis, and small molecules that increase lactate production by stimulating Myc levels or inhibiting Mpc1 carrier activity and can topically induce the hair cycle are identified.

TL;DR: High-throughput transcriptomics and metabolomics show that the liver has independent circadian functions specific for metabolic processes such as the NAD+ salvage pathway and glycogen turnover, but although BMAL1 occupies chromatin at most genomic targets in Liver-RE mice, circadian expression is restricted to ∼10% of normally rhythmic transcripts.

TL;DR: It is speculated that in humans the circadian clock imposes regulation of epidermal cell proliferation so that skin is at a particularly vulnerable stage during times of maximum UV exposure, thus contributing to the high incidence of human skin cancers.

TL;DR: The process of melanocyte stem cell entry into the quiescent state is described and it is shown that niche-derived transforming growth factor beta (TGF-beta) signaling plays important roles in this process.