Journal Article10.1016/J.EJMECH.2014.02.063
Isoxazoline containing natural products as anticancer agents: a review.
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TL;DR: This review mainly focuses on the existence of isoxazoline derivatives in natural sources, their isolation and uses there of as anticancer agents besides highlighting the synthetic pathways to achieve these compounds.
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About: This article is published in European Journal of Medicinal Chemistry. The article was published on 22 Apr 2014.
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Citations
β-Ionone and its analogs as promising anticancer agents.
Mahsa Ansari,Saeed Emami +1 more
TL;DR: The potentialities of β-ionone and related compounds in cancer prevention and chemotherapy are reviewed, finding compounds which can be used in combination regimes thus overcoming tumor resistance to conventional anticancer agents.
87
Synthesis of Chiral Tertiary Boronic Esters by Oxime-Directed Catalytic Asymmetric Hydroboration.
TL;DR: It is reported that the oxime-directed CAHB of alkyl-substituted methylidene and trisubstituting alkene substrates by pinacolborane (pinBH) affords oxime -containing chiral tertiary boronic esters with yields up to 87% and enantiomeric ratios up to 96:4 e.r.l.
84
Trifluoromethylpyrazoles as anti-inflammatory and antibacterial agents: A review
TL;DR: In the recent past trifluoromethyl pyrazoles have gained much attention, particularly as anti-inflammatory and antibacterial agents, in the field of medicinal chemistry.
72
Trichloroisocyanuric Acid Promoted Cascade Cyclization/Trifluoromethylation of Allylic Oximes: Synthesis of Trifluoromethylated Isoxazolines.
Weigang Zhang,Yingpeng Su,Ke-Hu Wang,Lili Wu,Bingbing Chang,Ya Shi,Danfeng Huang,Yulai Hu,Yulai Hu +8 more
TL;DR: The TMSCF3 method provides a novel and efficient protocol for the construction of CF3-containing 4,5-dihydroisoxazoles from allylic oximes in good to excellent yields.
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References
Natural Products as Sources of New Drugs over the Last 25 Years
David J. Newman,Gordon M. Cragg +1 more
TL;DR: This review is an updated and expanded version of two prior reviews that were published in this journal in 1997 and 2003 and is able to identify only one de novo combinatorial compound approved as a drug in this 25 plus year time frame.
Pyrazole containing natural products: Synthetic preview and biological significance
TL;DR: The present review is an attempt to understand the chemistry along with medicinal importance of pyrazole containing natural products reported till date which would certainly help the scientific community to bring further developments in the isolation and synthetic methodologies for pyrazoles based novel bioactive compounds.
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New pyrazole derivatives containing 1,2,4-triazoles and benzoxazoles as potent antimicrobial and analgesic agents
TL;DR: The results revealed that the compound 11c having 2,5-dichlorothiophene substituent on pyrazole moiety and a triazole ring showed significant analgesic and antimicrobial activity.
305
Design and synthesis of novel 1,2,3-triazole-dithiocarbamate hybrids as potential anticancer agents.
TL;DR: Flow cytometry analysis demonstrated that treatment of MGC-803 with 3c led to cell cycle arrest at G2/M phase accompanied by an increase in apoptotic cell death after 12 h, and compound 3a was more potent than 5-fluorouracil against all tested human cancer cell lines.
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•Journal Article
Natural sources as potential anti-cancer agents: A review
TL;DR: In this paper, a review of active principle derived from natural products is presented, which offers a great opportunity to evaluate not only totally new chemical classes of anticancer agents, but also novel lead compound and potentially relevant mechanisms of action.
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