Journal Article10.1016/0006-291X(80)90836-0
Isolation and characterization of a mannan-binding protein from rabbit liver
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TL;DR: It is proposed that the mannan-binding protein is the principle mediating the hepatic uptake of glycoproteins with terminal N-acetylglucosamine and/or mannose residues which are cleared rapidly from the circulation by the liver.
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About: This article is published in Biochemical and Biophysical Research Communications. The article was published on 14 Apr 1978. The article focuses on the topics: Mannan binding & Mannan.
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Citations
The human mannose-binding protein functions as an opsonin.
TL;DR: It is shown that native and recombinant human MBP can serve in an opsonic role in serum and thereby enhance clearance of mannose rich pathogens by phagocytes, demonstrating that MBP plays a role in first line host defense against certain pathogenic organisms.
Mannan-binding-lectin-associated serine proteases, characteristics and disease associations
TL;DR: Inherited MASP-2 deficiency has been described as the result of a mutation causing the exchange of aspartic acid with a glycine at position 105, a position in the first domain, CUB1, involved in calcium binding, which abolishes the binding to MBL and ficolins, and deprives MASp-2 of functional activity.
Preclinical studies of [99mTc]DTPA-mannosyl-dextran☆ ☆
TL;DR: This preclinical study demonstrates that [(99m)Tc]DTPA-mannosyl-dextran has no toxicities and has an acceptable biodistribution and radiation dose.
Deposition of Mannan Binding Protein and Mannan Binding Protein-Mediated Complement Activation in the Glomeruli of Patients with IgA Nephropathy
Mitsuhiro Matsuda,Kenichi Shikata,Jun Wada,Hikaru Sugimoto,Yasushi Shikata,Toshisuke Kawasaki,Hirofumi Makino +6 more
TL;DR: The presence of MBP and MBP-mediated complement activation in renal glomeruli of IgA nephropathy patients using an immunohistochemical method suggested that MBP was involved inglomerular complement activation through the lectin pathway and thus induced glomerular injury of Ig a nephrophobia.
The Role of Carbohydrate in Erythropoietin Action
TL;DR: The findings indicate that the oligosaccharide portion of epo, although required for action in vivo, is not required for interaction with the target cells of the blood-forming system.
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TL;DR: Inherent advantages of this method of purification are the rapidity and ease of a potentially single-step procedure, the rapid separation of the protein to be purified from inhibitors and destructive contaminants, such as proteases, and protection from denaturation during purification by active site ligand-stabilization of protein tertiary structure.
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Comparative Aspects of Glycoprotein Structure
TL;DR: Of all the biologically occurring macromolecules the glycoproteins, which consist of carbohydrate moieties convalently linked to a polypeptide backbone, represent the most diverse group, ranging from substances in which the carbohydrate component represents less than 1% of the total weight to those in which it represents over 80% ofThe total.
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The isolation and properties of a rabbit liver binding protein specific for asialoglycoproteins.
Roger L. Hudgin,Roger L. Hudgin,W.E. Pricer,W.E. Pricer,Gilbert Ashwell,Gilbert Ashwell,Richard J. Stockert,Richard J. Stockert,A G Morell,A G Morell +9 more
TL;DR: The purification, by affinity chromatography, of an hepatic protein which retains the characteristic binding properties associated with the membranes is described, which indicates a high degree of aggregation in the final, water-soluble preparation.
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