Journal Article10.1016/0006-2952(95)00181-6
Isoforms of nitric oxide synthase. Properties, cellular distribution and expressional control.
503
TL;DR: Information on NOS has increased to such an extent that this new commentary had to be restricted to some important biochemical aspects of the NOS enzymes, namely their protein and cDNA structure, their cellular distribution, and the mechanism controlling their expression.
read more
About: This article is published in Biochemical Pharmacology. The article was published on 26 Oct 1995. The article focuses on the topics: Soluble guanylyl cyclase & Isozyme.
read more
Chat with Paper
AI Agents for this Paper
Find similar papers on Google Scholar, PubMed and Arxiv
Write a critical review of this paper
Analyze citations of this paper to find unaddressed research gaps
Citations
Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation
Stefanie Dimmeler,Ingrid Fleming,Beate Fisslthaler,Corinna Hermann,Rudi Busse,Andreas M. Zeiher +5 more
TL;DR: It is demonstrated that the serine/threonine protein kinase Akt/PKB mediates the activation of eNOS, leading to increased NO production, and represents a novel Ca2+-independent regulatory mechanism for activation ofeNOS.
3.7K
Regulation of the Hypothalamic-Pituitary-Adrenal Axis by Cytokines: Actions and Mechanisms of Action
TL;DR: Findings are reviewed that have documented which cytokines have been shown to influence hormone secretion from the HPA axis, determined under what physiological/pathophysiological circumstances endogenous cytokines regulate HPAaxis activity, established the possible sites of cytokine action on HPA Axis hormone secretion, and identified the potential neuroanatomic and pharmacological mechanisms by which cytokine signal the neuroendocrine hypothalamus.
1.3K
Free Radical Pathways in CNS Injury
TL;DR: It is concluded here that substantial experimental data links oxidative stress with other pathogenic mechanisms such as excitotoxicity, calcium overload, mitochondrial cytochrome c release, caspase activation, and apoptosis in central nervous system (CNS) trauma and ischemia, and that utilization of genetically manipulated animals offers a unique possibility to elucidate the role of free radicals in CNS injury in a molecular fashion.
809
Regulation of the expression of inducible nitric oxide synthase
TL;DR: Post-transcriptional mechanisms involving a complex network of RNA-binding proteins build up by AUF1, HuR, KSRP, PTB and TTP is critically involved in the regulation of iNOS expression.
509
References
Steroid hormones modulate the production of nitric oxide and cGMP in the rat uterus.
TL;DR: Evidence is provided that the NO-cGMP system is upregulated during pregnancy to maintain uterine quiescence and a rise in estrogen at term could inhibit this system and thus initiate labor.
124
Hepatocytes and macrophages express an identical cytokine inducible nitric oxide synthase gene.
TL;DR: The predicted amino acid sequence of rat hepatocyte inducible NOS is 94% identical with that from the mouse macrophage cell line, RAW264, and differences are most likely the result of species variability which suggests that hepatocytes and macrophages express the same NOS gene upon induction.
121
•Journal Article
Hormone-induced biosynthesis of endothelium-derived relaxing factor/nitric oxide-like material in N1E-115 neuroblastoma cells requires calcium and calmodulin.
U. Förstermann,L. D. Gorsky,Jennifer S. Pollock,Kunio Ishii,Harald H.H.W. Schmidt,Michael Heller,Ferid Murad +6 more
TL;DR: The activity of the EDRF/NO-synthesizing enzyme(s) in N1E-115 neuroblastoma cells is regulated by Ca2+ and calmodulin.
119
Identification of an endothelial-like type III NO synthase in LLC-PK1 kidney epithelial cells.
TL;DR: The identification and characterization of a constitutive, particulate nitric oxide (NO) synthase from LLC- PK1 cells and the presence of type III NO synthase mRNA in LLC-PK1 cells was demonstrated using the polymerase chain reaction.
116
Regulation of inducible nitric oxide synthase mRNA levels by LPS, INF-γ, TGF-β, and IL-10 in murine macrophage cell lines and rat peritoneal macrophages
TL;DR: The molecular mechanisms of LPS, INF-γ, TGF-β, and IL-10 regulation of inducible nitric oxide synthase (iNOS) mRNA expression were evaluated, and in human macrophages, the iNOS gene may have become inoperative during evolution.
116