Isoforms of nitric oxide synthase. Properties, cellular distribution and expressional control.

TL;DR: The authors revisar las diferentes formas por las que mediadores provocan la activación o sensibilización de terminales perifericas de neuronas nociceptivas.

TL;DR: Irbesartan, an AT1 antagonist, prevents fibrosis and inflammation and inhibits nitric oxide production in HOCl-induced models of systemic fibrosis, extending the indication of an AT 1 antagonist to SSc patients with diffuse fibrosis , especially those with lung involvement.

TL;DR: The constitutive NOS isoform in megakaryocytes and platelets is NOS III, whereas neutrophils express NOS I, using Western blot and fluorescent immunocytochemistry and RT-PCR.

TL;DR: In this article, les patients obeses et diabetiques souffrent de troubles of the motilite intestinale (in particular, de ces souris diabetique lors d'un repas) were investigated.

TL;DR: In this paper, it was shown that NO synthetase is a calmodulin-requiring enzyme, and showed that NO formation is accompanied by the stoichiometric conversion of arginine to citrulline.

TL;DR: Cloning of a complementary DNA for brain nitric oxide synthase reveals recognition sites for NADPH, FAD, flavin mononucleotide and calmodulin as well as phosphorylation sites, indicating that the synthase is regulated by many different factors.

TL;DR: The cloning, characterization and functional expression of cDNAs encoding rat brain nitric oxide synthase (NOS) are described, which is responsible for intracellular synthesis of NO from arginine, and the sequence reveals putative sites for interaction with calmodulin and for phosphorylation by cyclic AMP-dependent protein kinase.

TL;DR: It is suggested that synthesis of NO mediates much of the antimicrobial activity of mouse macrophages against some fungal, helminthic, protozoal and bacterial pathogens.