Journal Article10.1016/0006-2952(95)00181-6
Isoforms of nitric oxide synthase. Properties, cellular distribution and expressional control.
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TL;DR: Information on NOS has increased to such an extent that this new commentary had to be restricted to some important biochemical aspects of the NOS enzymes, namely their protein and cDNA structure, their cellular distribution, and the mechanism controlling their expression.
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About: This article is published in Biochemical Pharmacology. The article was published on 26 Oct 1995. The article focuses on the topics: Soluble guanylyl cyclase & Isozyme.
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Citations
Activation of nitric oxide synthase by ischaemia in the perfused heart.
TL;DR: No synthase activity in the heart is rapidly stimulated by ischaemia and this stimulation is maintained during the whole ischaemic episode, whereas the particulate activity is not affected by isCHAemia.
114
Nitric Oxide/Nitric Oxide Synthase, Spermatogenesis, and Tight Junction Dynamics
Nikki P.Y. Lee,C. Yan Cheng +1 more
TL;DR: Recent advances in the field regarding the role of NO in testicular function are summarized, with special emphasis regarding its role in TJ dynamics and the likely implications of these studies for male contraceptive development.
113
Targetable Fluorescent Probe for Monitoring Exogenous and Endogenous NO in Mitochondria of Living Cells
TL;DR: Mito-Rh-NO, the first mitochondria-targetable "turn-on" fluorescent probe for NO, has been developed through attaching a triphenylphosphonium to a rhodamine spirolactam and demonstrates high applicability for real-time monitoring of mitochondrial NO in live cells.
110
Association between Alzheimer's disease and the NOS3 gene.
M. T. Dahiyat,Alistair Cumming,Charles R. Harrington,Claude M. Wischik,John H. Xuereb,F Corrigan,Gerome Breen,Daniel J Shaw,D. St Clair +8 more
TL;DR: A highly significant enrichment for Glu/Glu homozygotes in LOAD compared with controls appears to be independent of ApoE status, and NOS3 may be a new genetic risk factor for LOAD.
105
Differential localization of neuronal nitric oxide synthase immunoreactivity and NADPH-diaphorase activity in the cat spinal cord.
TL;DR: The results of this study demonstrate that NADPH-d activity is not always a specific histochemical marker for NO-containing neural structures.
103
References
Isolation of nitric oxide synthetase, a calmodulin-requiring enzyme.
David S. Bredt,Solomon H. Snyder +1 more
TL;DR: It is shown that nitric oxide synthetase activity requires calmodulin, and the native enzyme appears to be a monomer.
3.4K
Isolation of nitric oxide synthetase, a calmodulin-requiring enzyme (endothelium-derived relaxing factor/arginine/cGMP)
David S. Bredt,Solomon H. Snyder +1 more
- 01 Jan 2016
TL;DR: In this paper, it was shown that NO synthetase is a calmodulin-requiring enzyme, and showed that NO formation is accompanied by the stoichiometric conversion of arginine to citrulline.
3K
Cloned and expressed nitric oxide synthase structurally resembles cytochrome P-450 reductase.
David S. Bredt,Paul M. Hwang,Charles E. Glatt,Charles J. Lowenstein,Randall R. Reed,Randall R. Reed,Solomon H. Snyder +6 more
TL;DR: Cloning of a complementary DNA for brain nitric oxide synthase reveals recognition sites for NADPH, FAD, flavin mononucleotide and calmodulin as well as phosphorylation sites, indicating that the synthase is regulated by many different factors.
2.4K
Cloned and expressed nitric oxide synthase structurally resembles cytochrome P-450 reductase
David S. Bredt,Paul M. Hwang,Charles E. Glatt,Charles J. Lowenstein,Randall R. Reed,Randall R. Reed,Solomon H. Snyder +6 more
TL;DR: The cloning, characterization and functional expression of cDNAs encoding rat brain nitric oxide synthase (NOS) are described, which is responsible for intracellular synthesis of NO from arginine, and the sequence reveals putative sites for interaction with calmodulin and for phosphorylation by cyclic AMP-dependent protein kinase.
1.6K
Role of nitric oxide synthesis in macrophage antimicrobial activity.
TL;DR: It is suggested that synthesis of NO mediates much of the antimicrobial activity of mouse macrophages against some fungal, helminthic, protozoal and bacterial pathogens.
1.6K