Journal Article10.1016/0006-2952(95)00181-6
Isoforms of nitric oxide synthase. Properties, cellular distribution and expressional control.
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TL;DR: Information on NOS has increased to such an extent that this new commentary had to be restricted to some important biochemical aspects of the NOS enzymes, namely their protein and cDNA structure, their cellular distribution, and the mechanism controlling their expression.
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About: This article is published in Biochemical Pharmacology. The article was published on 26 Oct 1995. The article focuses on the topics: Soluble guanylyl cyclase & Isozyme.
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Citations
Differential distribution of nitric oxide synthase in neural pathways to the urogenital organs (urethra, penis, urinary bladder) of the rat
TL;DR: The results suggest that the contribution of nitric oxide (NO) to neurotransmission varies considerably in different urogenital organs.
152
Regulation of Inducible Nitric Oxide Synthase (iNOS) and its Potential Role in Insulin Resistance, Diabetes and Heart Failure
Sanja Soskic,Branislava Dobutovic,Emina Sudar,Milan Obradovic,Dragana Nikolic,Jelena D Djordjevic,Djordje Radak,Dimitri P. Mikhailidis,Esma R. Isenovic +8 more
TL;DR: This review considers the recent animal studies which focus on the understanding of regulation of iNOS activity/expression and the role of i NOS agonists as potential therapeutic agents in treatment of IR, T2DM and HF.
Differential regulation of inducible and endothelial nitric oxide synthase by kinin B1 and B2 receptors.
TL;DR: In this article, a review of the different transduction events that take place upon B2R and B1R activation in human endothelial cells that leads to generation of NO via activation of different NOS isoforms.
149
Nitric oxide synthase expression and role during cardiomyogenesis.
Wilhelm Bloch,Bernd K. Fleischmann,Dietrich E. Lorke,Christian Andressen,B Hops,Juergen Hescheler,Klaus Addicks +6 more
TL;DR: It is demonstrated that continuous incubation of EBs with the NOS inhibitors L-NMMA or L-NA for 4 to 9 days after plating resulted in a pronounced differentiation arrest of cardiomyocytes, whereas this effect could be reversed by coapplication of the NO-donor spermine-NONOate (10 microM).
Anti-inflammatory effects of hydroxycinnamic acid derivatives.
Reiko Nagasaka,Chatchawan Chotimarkorn,Islam Md. Shafiqul,Masatoshi Hori,Hiroshi Ozaki,Hideki Ushio +5 more
TL;DR: Cycloartenyl ferulate, one of phytosteryl ferulates, significantly reduced lipopolysaccharide (LPS)-induced NO production and mRNA expression of inducible NO synthase and cyclooxygenese-2 but upregulated SOD activity and inhibited DNA-binding of NF-kappaB.
143
References
Isolation of nitric oxide synthetase, a calmodulin-requiring enzyme.
David S. Bredt,Solomon H. Snyder +1 more
TL;DR: It is shown that nitric oxide synthetase activity requires calmodulin, and the native enzyme appears to be a monomer.
3.4K
Isolation of nitric oxide synthetase, a calmodulin-requiring enzyme (endothelium-derived relaxing factor/arginine/cGMP)
David S. Bredt,Solomon H. Snyder +1 more
- 01 Jan 2016
TL;DR: In this paper, it was shown that NO synthetase is a calmodulin-requiring enzyme, and showed that NO formation is accompanied by the stoichiometric conversion of arginine to citrulline.
3K
Cloned and expressed nitric oxide synthase structurally resembles cytochrome P-450 reductase.
David S. Bredt,Paul M. Hwang,Charles E. Glatt,Charles J. Lowenstein,Randall R. Reed,Randall R. Reed,Solomon H. Snyder +6 more
TL;DR: Cloning of a complementary DNA for brain nitric oxide synthase reveals recognition sites for NADPH, FAD, flavin mononucleotide and calmodulin as well as phosphorylation sites, indicating that the synthase is regulated by many different factors.
2.4K
Cloned and expressed nitric oxide synthase structurally resembles cytochrome P-450 reductase
David S. Bredt,Paul M. Hwang,Charles E. Glatt,Charles J. Lowenstein,Randall R. Reed,Randall R. Reed,Solomon H. Snyder +6 more
TL;DR: The cloning, characterization and functional expression of cDNAs encoding rat brain nitric oxide synthase (NOS) are described, which is responsible for intracellular synthesis of NO from arginine, and the sequence reveals putative sites for interaction with calmodulin and for phosphorylation by cyclic AMP-dependent protein kinase.
1.6K
Role of nitric oxide synthesis in macrophage antimicrobial activity.
TL;DR: It is suggested that synthesis of NO mediates much of the antimicrobial activity of mouse macrophages against some fungal, helminthic, protozoal and bacterial pathogens.
1.6K