Journal Article10.1016/0006-2952(95)00181-6
Isoforms of nitric oxide synthase. Properties, cellular distribution and expressional control.
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TL;DR: Information on NOS has increased to such an extent that this new commentary had to be restricted to some important biochemical aspects of the NOS enzymes, namely their protein and cDNA structure, their cellular distribution, and the mechanism controlling their expression.
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About: This article is published in Biochemical Pharmacology. The article was published on 26 Oct 1995. The article focuses on the topics: Soluble guanylyl cyclase & Isozyme.
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Citations
Expression patterns of cytokines, p53 and nitric oxide synthase isoenzymes in corpora lutea of pseudopregnant rabbits during spontaneous luteolysis.
Cristiano Boiti,Gabriella Guelfi,Massimo Zerani,Danilo Zampini,Gabriele Brecchia,Anna Gobbetti +5 more
TL;DR: A physiological role of NO as modulator of luteal demise in rabbits is supported, while downstream NO may inhibit steroroidogenesis and induce expression of p53 gene after removal of the protective action of progesterone.
A ratiometric mitochondria-targeting two-photon fluorescent probe for imaging of nitric oxide in vivo.
TL;DR: The successful two-photon imaging of mitochondrial NO proved that Mito-N is a powerful noninvasive imaging tool in living systems.
31
Novel Experimental Strategies to Prevent the Development of Type 1 Diabetes Mellitus
Stellan Sandler,Annika K. Andersson,Andreea Barbu,Claes Hellerström,Maria Holstad,Ella Karlsson,Jan-Olov Sandberg,E Strandell,Johan Saldeen,Johnny Sternesjö,Linda Tillmar,Decio L. Eizirik,Malin Flodström,Nils Welsh +13 more
TL;DR: The research focusses on the role of β-cells during the course of the disease, aiming at finding novel strategies to enhance β-cell resistance against the cytotoxic damage inflicted by the immune system, and applies gene therapeutic approaches to increase expression of protective genes inβ-cells.
31
Lead acetate exposure inhibits nitric oxide synthase activity in capillary and synaptosomal fractions of mouse brain.
TL;DR: Data suggest that inhibition of cNOS activity and increase in iNOS may contribute to the Pb effects on the CNS, and the concentration of lead in blood, capillaries and synaptosomes in brain from mice receiving 0, 250, 500, and 1000 ppm of lead for 14 days through the drinking water.
31
Expression and localization of inducible nitric oxide synthase in human non-pregnant and early pregnant endometrium
TL;DR: The finding of a large amount of iNOS mRNA at the feto-maternal interface throughout the first trimester of pregnancy suggests that iNos may play an important role in the maintenance of pregnancy.
31
References
Isolation of nitric oxide synthetase, a calmodulin-requiring enzyme.
David S. Bredt,Solomon H. Snyder +1 more
TL;DR: It is shown that nitric oxide synthetase activity requires calmodulin, and the native enzyme appears to be a monomer.
3.4K
Isolation of nitric oxide synthetase, a calmodulin-requiring enzyme (endothelium-derived relaxing factor/arginine/cGMP)
David S. Bredt,Solomon H. Snyder +1 more
- 01 Jan 2016
TL;DR: In this paper, it was shown that NO synthetase is a calmodulin-requiring enzyme, and showed that NO formation is accompanied by the stoichiometric conversion of arginine to citrulline.
3K
Cloned and expressed nitric oxide synthase structurally resembles cytochrome P-450 reductase.
David S. Bredt,Paul M. Hwang,Charles E. Glatt,Charles J. Lowenstein,Randall R. Reed,Randall R. Reed,Solomon H. Snyder +6 more
TL;DR: Cloning of a complementary DNA for brain nitric oxide synthase reveals recognition sites for NADPH, FAD, flavin mononucleotide and calmodulin as well as phosphorylation sites, indicating that the synthase is regulated by many different factors.
2.4K
Cloned and expressed nitric oxide synthase structurally resembles cytochrome P-450 reductase
David S. Bredt,Paul M. Hwang,Charles E. Glatt,Charles J. Lowenstein,Randall R. Reed,Randall R. Reed,Solomon H. Snyder +6 more
TL;DR: The cloning, characterization and functional expression of cDNAs encoding rat brain nitric oxide synthase (NOS) are described, which is responsible for intracellular synthesis of NO from arginine, and the sequence reveals putative sites for interaction with calmodulin and for phosphorylation by cyclic AMP-dependent protein kinase.
1.6K
Role of nitric oxide synthesis in macrophage antimicrobial activity.
TL;DR: It is suggested that synthesis of NO mediates much of the antimicrobial activity of mouse macrophages against some fungal, helminthic, protozoal and bacterial pathogens.
1.6K