Journal Article10.1097/GME.0B013E3181ECF9B9
Isoflavones decrease insomnia in postmenopause.
Helena Hachul,Letícia de Campos Brandão,Vânia D'Almeida,Lia Bittencourt,Edmund Chada Baracat,Sergio Tufik +5 more
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TL;DR: In postmenopausal women with insomnia, isoflavone treatment was effective in reducing insomnia symptoms, which was confirmed by increased sleep efficiency as observed by polysomnographic analysis.
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Abstract: Objective Most postmenopausal women have insomnia. Some of these women also have respiratory sleep disorders. Recent reports have documented that the phytohormones, isoflavones, are capable of reducing the symptoms of climacterium. The purpose of this investigation was to examine subjective and objective sleep parameters and to measure changes in these parameters during treatment with isoflavones in a controlled, double-blinded study in postmenopausal women with insomnia. Methods Two groups of postmenopausal women with insomnia participated in the study: the first received 80 mg isoflavones daily for 4 months, and the second received a placebo for the same period. Sleep analysis consisted of questionnaires and polysomnography. Student's t test and analysis of variance were applied for comparisons between groups, and correlations were tested with Pearson's correlation coefficient. Results Thirty-eight women were enrolled in the study. Polysomnography revealed a significant increase in sleep efficiency in the isoflavone group (from 77.9% to 83.9%) when compared with the placebo group (from 77.6% to 81.2%). Isoflavones induced a decrease in the intensity and number of hot flashes and the frequency of insomnia: among the women in the placebo group, 94.7% had moderate or intense insomnia at the beginning of the study, compared with 63.2% at the end, whereas in the isoflavone group, these percentages were 89.5% and 36.9%, respectively. Conclusions In postmenopausal women with insomnia, isoflavone treatment was effective in reducing insomnia symptoms, which was confirmed by increased sleep efficiency as observed by polysomnographic analysis.
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Citations
Use of Plant-Based Therapies and Menopausal Symptoms: A Systematic Review and Meta-analysis.
Oscar H. Franco,Rajiv Chowdhury,Jenna Troup,Trudy Voortman,Setor K Kunutsor,Maryam Kavousi,Clare Oliver-Williams,Taulant Muka,Taulant Muka +8 more
TL;DR: This meta-analysis of clinical trials suggests that composite and specific phytoestrogen supplementations were associated with modest reductions in the frequency of hot flashes and vaginal dryness but no significant reduction in night sweats.
Extracted or synthesized soybean isoflavones reduce menopausal hot flash frequency and severity: systematic review and meta-analysis of randomized controlled trials
TL;DR: Soy isoflavone supplements, derived by extraction or chemical synthesis, are significantly more effective than placebo in reducing the frequency and severity of hot flashes.
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Current Perspectives on the Beneficial Effects of Soybean Isoflavones and Their Metabolites for Humans.
TL;DR: Genistein, an isoflavone, has cancer-suppressing effects on estrogen receptor-positive (ER+) cancers, including breast cancer, and it also has positive effects on menstrual irregularity in nonmenopausal women and relieving menopausal symptoms in middle-aged women as mentioned in this paper.
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Sleep and Women's Health
Sara Nowakowski,Jessica M. Meers,Erin Heimbach +2 more
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TL;DR: A discussion on the most relevant and recent publications on sleep across the woman's lifespan, including changes in sleep related to menstruation, pregnancy, postpartum, and the menopausal transition is presented.
Vasomotor symptoms resulting from natural menopause: a systematic review and network meta-analysis of treatment effects from the National Institute for Health and Care Excellence guideline on menopause.
TL;DR: For women who have not undergone hysterectomy, transdermal estradiol and progestogen (O+P) was the most effective treatment for VMS relief as discussed by the authors.
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Soy isoflavones have a favorable effect on bone loss in Chinese postmenopausal women with lower bone mass: a double-blind, randomized, controlled trial.
TL;DR: Soy isoflavones have a mild, but significant, independent effect on the maintenance of hip BMC in postmenopausal women with low initial bone mass in this double-blind, placebo-controlled, randomized trial.
Sleep disruption and mood changes associated with menopause
TL;DR: Results suggest that the mood changes experienced by the perimenopausal group may be mediated by sleep disruption, which is significantly related to age and sociodemographic variables.
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Lack of sleep disturbance from menopausal hot flashes
Robert Freedman,Timothy Roehrs +1 more
TL;DR: These data provide no evidence that hot flashes produce sleep disturbance in symptomatic postmenopausal women, and previous reports of increased sleep disturbance at menopause may be due to disorders that were screened out, such as sleep apnea and drug use.
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The Thermoregulatory Effects of Menopausal Hot Flashes on Sleep
Suzanne Woodward,Robert Freedman +1 more
TL;DR: The results show that hot flashes are associated with increased Stage 4 sleep and a shortened first rapid eye movement period and the central thermoregulatory mechanism underlying hot flashes may affect hypnogenic pathways inducing sleep and heat loss in the absence of a thermal load.
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