Ischemic time-dependent microvascular changes and reperfusion injury in the rat small intestine.

TL;DR: This review assesses currently used porcine models of gastrointestinal physiology and disease and provides a rationale for the use of these models for future translational studies.

TL;DR: An outline of current knowledge is provided on the mechanisms and consequences of IRI, which appears to be mediated by reactive oxygen metabolites and, at a later stage, by the priming and activation of polymorphonuclear neutrophils (PMN).

TL;DR: Invasive and non-invasive techniques for the diagnosis and quantification of CMD in STEMI in the clinical setting as well as results from experimental in vitro and in vivo models focusing on ischaemic-, reperfusion-, and inflammatory damage to the coronary microvascular endothelial cells are discussed.

TL;DR: The study provides evidence that exogenous methane modulates leukocyte activation and affects key events of ischemia–reperfusion-induced oxidative and nitrosative stress and is therefore of potential therapeutic interest in inflammatory pathologies.