Is factor V Leiden mutation a cause of in vitro fertilization failure

TL;DR: Higher sperm counts and more successful embryo implantation seem to play a role in the increased fecundity, and activated protein C (APC) levels possibly mediate anti-inflammatory effects.

TL;DR: In women undergoing IVF, the presence of two or more thrombophilic defects was rare and showed no statistically significant associations with IVF outcomes.

TL;DR: Prospective studies have failed to establish a definitive link between inherited thrombophilias and stillbirth, and the extant literature suggests that only high concentrations of antiphospholipid antibodies are associated with stillbirth.

TL;DR: In this paper, the role of the hemostatic system in the process of implantation is examined, as well as evidence addressing the relationship between ART and thromboembolism is examined.

TL;DR: It is confirmed that women with thrombophilia are at risk of developing venous thromboembolism and complications in pregnancy, however, despite the increase in relative risk, the absolute risk of VTE and adverse outcomes remains low.

TL;DR: It is indicated that prevalence of factor V Leiden is greater among Caucasians than minority Americans, and this data have implications for clinicians considering whether to screen for factor VLeiden in high-risk groups such as those with prior venous thromboses or coexistent defects of anticoagulation and women at risk for postpartum thromBosis or seeking oral contraceptives.

TL;DR: Women with repeated IVF-embryo transfer failure should be screened for thrombophilia, which has a significant role in IVF and embryo transfer implantation failure.

TL;DR: This study provides no evidence for an association between maternal thrombophilia and failure to achieve pregnancy after assisted reproductive procedures, and routine anticoagulant treatment in women undergoing assisted reproductive procedure is not warranted.