Is age a risk factor for Candida glabrata colonisation
TL;DR: In this paper, the authors sought to determine colonisation rates of C. glabrata in the oral cavity and its relationship with age, comorbid illnesses and hospital or extended care facility stay.
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Abstract: Summary Studies have reported that Candida glabrata infections are more common in older adults. We sought to determine colonisation rates of C. glabrata in the oral cavity and its relationship with age, comorbid illnesses and hospital or extended care facility stay. Samples were obtained from four sites in the oral cavity and from dentures, when available, from 408 subjects from the community (136), hospital (126) or an extended care facility (146). Overall, 219 (53.7%) subjects were colonised with yeast; the predominant species was Candida albicans. Sixty-two patients (15.2%) were colonised with C. glabrata. None of the subjects 60 years, were colonised with C. glabrata. By multivariate analysis, increasing age, dentures and use of psychotropic medications were independently associated with C. glabrata colonisation; residing in the community, rather than hospital or extended care, was strongly protective against colonisation. Candida glabrata colonisation is multifactorial; age, and hospitalisation ⁄extended care stay contribute to colonisation. Dentures are strongly associated with colonisation with any yeast and with C. glabrata. Further study is needed to evaluate the relationship of these findings to increasing C. glabrata infections in older adults.
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Citations
Oral Candida isolates and fluconazole susceptibility patterns in older Mexican women
Beatriz Benito-Cruz,Saray Aranda-Romo,Francisco Javier López-Esqueda,Estela de la Rosa-García,Rebeca Rosas-Hernández,Luis Octavio Sánchez-Vargas +5 more
TL;DR: After 80 years of age, there is a considerable increase in Candida non-albicans species and a reduced susceptibility to fluconazole.
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Epidemiology of Candidemia: Three-Year Results from a Croatian Tertiary Care Hospital.
Ivana Mareković,Sanja Pleško,Violeta Rezo Vranješ,Zoran Herljević,Tomislav Kuliš,Marija Jandrlić +5 more
TL;DR: In this article, the authors described epidemiology, risk factors and species distribution in patients with candidemia in a three-year retrospective observational study, from 2018 to 2020, was performed at the University Hospital Centre Zagreb, Zagria, Croatia.
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Candida glabrata : Multidrug Resistance and Increased Virulence in a Major Opportunistic Fungal Pathogen
TL;DR: Recent findings suggest that gain of function (GOF) mutations in the transcriptional regulator CgPdr1p results not only in broad resistance to azole antifungals but also an increase in both fitness and virulence in animal models.
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Oral frailty and carriage of oral Candida in community-dwelling older adults (Check-up to discover Health with Energy for senior Residents in Iwamizawa; CHEER Iwamizawa).
Haruhisa Baba,Yutaka Watanabe,Kazuhito Miura,Kimiya Ozaki,Takae Matsushita,Miyako Kondoh,Kazutaka Okada,Akira Hasebe,Tokiyoshi Ayabe,Kiminori Nakamura,Shinji Nakaoka,Katsuhiko Ogasawara,Teppei Suzuki,Hiroshi Saito,Takashi Kimura,Akiko Tamakoshi,Yutaka Yamazaki +16 more
TL;DR: Basic data was obtained useful for intervention studies aimed at verifying whether oral function management prevents deterioration of the oral bacterial flora.
Niacin Limitation Promotes Candida glabrata Adhesion to Abiotic Surfaces
TL;DR: NA limitation resulted in increased expression of some adhesion genes, higher surface hydrophobicity of C. glabrata cells, and enhanced adhesion to abiotic surfaces.
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