1. What have the authors contributed in "Ionic cocrystals of pharmaceutical compounds: sodium complexes" ?
In this paper, the authors described a series of nH2O-based ICM structures that contain metal cations and acridinium.
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2. What is the name of the drug used in the treatment of epilepsy?
22 Carbemazepine (CBZ) is the anticonvulsant drug used in the 23 treatment of epilepsy that has become one of the best known 24 model compounds used in solid state form identification and 25 characterization studies.
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3. What is the common grouping of CBZ?
Approximately half of the 32 crystal coformers used with CBZ are neutral carboxylic acids4−7 33 with organic solvates making up the next biggest grouping.
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4. What is the structure of the CBZ ligands?
In each 229complex, each of the amide NH2 groups of the four basal CBZ 230ligands donates a single intramolecular hydrogen bond to the 231amide O atom acceptor of the neighboring basal CBZ ligand.
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![Figure 1. Molecular structure of [Na(CBZ)4(MeOH)][I]·H2O. Disorder in the solvent and all nonamide hydrogen atoms have been omitted for clarity. Here and elsewhere, hydrogen bonds are shown as light blue lines.](/figures/figure-1-molecular-structure-of-na-cbz-4-meoh-i-h2o-disorder-d9f1fdi7.webp)
![Figure 2. Molecular structure of the cation in [Na(CBZ)5][I3]. Nonamide hydrogen atoms have been omitted for clarity.](/figures/figure-2-molecular-structure-of-the-cation-in-na-cbz-5-i3-1gd59qxl.webp)
![Figure 8. Close packed dimer of CBZ molecules found in the structure of [Na(CBZ)][I3]. This is supramolecular construct B in ref 11. Similar interactions can be found in the structure of [Na(CBZ)5][C13H10N][IBr2]2.](/figures/figure-8-close-packed-dimer-of-cbz-molecules-found-in-the-1pqedoqb.webp)
![Figure 6. Part of the hydrogen bonding motif found in the structure of [NH4][Br][CBZ]. Bromide ions drawn as brown spheres.](/figures/figure-6-part-of-the-hydrogen-bonding-motif-found-in-the-2el25q60.webp)
![Figure 7. Translational stack of CBZ molecules found in the structure of [Na(CBZ)4(MeOH)][I]·H2O. This is supramolecular construct A in ref 11. In this case, the translation is along the crystallographic b axis and hence along the Na−O(MeOH) molecular axis.](/figures/figure-7-translational-stack-of-cbz-molecules-found-in-the-3je6dllf.webp)