Journal Article10.1111/PIN.12910
Invasive breast cancer: Current perspectives and emerging views.
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TL;DR: This article reviews conventional prognostic parameters, new histological entities, and updates on breast cancer classification, with inclusion of some genetic insights into breast cancer and the role of tumor infiltrating lymphocytes.
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Abstract: Invasive breast cancer constitutes a heterogeneous group of tumors. They comprise various histological types that differ in clinical presentation, imaging features, histopathological characteristics, biomarker profiles, prognostic and predictive parameters. The current classification of invasive breast cancer is based primarily on histopathological features. Invasive carcinoma of no special type accounts for the majority, with some rare entities also being described. With recent research and advances, there are emerging concepts, including new genetic insights of invasive breast cancer and the role of the stromal microenvironment. With greater understanding of the pathogenesis of invasive breast cancer, changes based on the correlation of histologic and genetic findings have been incorporated in the latest World Health Organization classification of breast tumors. Medullary carcinomas are subsumed as invasive carcinoma of no special type with basal-like and medullary features, regarded as part of the spectrum of tumor infiltrating lymphocyte-rich breast cancers. Tall cell carcinoma with reversed polarity is proposed as a distinct entity in recognition of unique IDH2 mutations. This article reviews conventional prognostic parameters, new histological entities, and updates on breast cancer classification, with inclusion of some genetic insights into breast cancer and the role of tumor infiltrating lymphocytes.
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Citations
Human Epidermal Growth Factor Receptor 2 Testing in Breast Cancer: American Society of Clinical Oncology/College of American Pathologists Clinical Practice Guideline Focused Update
Antonio C. Wolff,M. Elizabeth H. Hammond,Kimberly H. Allison,Brittany E. Harvey,Pamela B. Mangu,John M. S. Bartlett,Michael Bilous,Ian O. Ellis,Patrick L. Fitzgibbons,Wedad Hanna,Robert B. Jenkins,Michael F. Press,Patricia A. Spears,Gail H. Vance,Giuseppe Viale,Lisa M. McShane,Mitchell Dowsett +16 more
- 01 Jan 2018
TL;DR: In this article, the authors updated key recommendations of the American Society of Clinical Oncology (ASCO)/College of American Pathologists (CAP) human epidermal growth factor receptor 2 (HER2) testing in breast cancer.
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Emad A. Rakha,Jorge S. Reis-Filho,Frederick L. Baehner,David J. Dabbs,Thomas Decker,Vincenzo Eusebi,Stephen B. Fox,Shu Ichihara,Jocelyne Jacquemier,Sunil R. Lakhani,José Palacios,Andrea L. Richardson,Stuart J. Schnitt,Fernando Schmitt,Puay Hoon Tan,Gary M.K. Tse,Sunil V. Badve,Ian O. Ellis +17 more
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TL;DR: An analysis of the validity of Histological grade as a prognostic factor and a consensus view on the significance of histological grade and its role in breast cancer classification and staging systems in this era of emerging clinical use of molecular classifiers are presented.
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Sylvia Adams,Robert Gray,Sandra Demaria,Lori J. Goldstein,Edith A. Perez,Lawrence N. Shulman,Silvana Martino,Molin Wang,Vicky Jones,Thomas J. Saphner,Antonio C. Wolff,William C. Wood,Nancy E. Davidson,George W. Sledge,Joseph A. Sparano,Sunil Badve +15 more
- 01 Jan 2014
TL;DR: In this article, the authors validate the prognostic impact of tumor-infiltrating lymphocytes (TILs) in primary triple-negative breast cancer (TNBC) in two adjuvant phase III trials conducted by the Eastern Cooperative Oncology Group (ECOG).
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Correlation Analysis of Pathological Features and Axillary Lymph Node Metastasis in Patients with Invasive Breast Cancer
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Gene expressions and their significance in organoid cultures obtained from breast cancer patient-derived biopsies.
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TL;DR: In this article , the authors present the genes implicated in breast cancers, the ways in which organoids can be derived from breast cancer biopsies and their applications for gene expression studies.
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