Invariant NKT Cells Suppress CD8+ T-Cell–Mediated Allergic Contact Dermatitis Independently of Regulatory CD4+ T Cells

TL;DR: The present review attempts to provide a critical appraisal of the hapten-mediated tumor treatments and offers insights for future development of the field.

TL;DR: Adaptive features of the innate immune system as well as heterologous innate immunity and their implications are discussed and have many implications for understanding of individual susceptibility to diseases or responsiveness to therapies and vaccinations.

TL;DR: The diversity of innate lymphocytes and lymphoid cells found in mammalian skin with a special focus on αβ T cells, Natural Killer T cells and Innate Lymphoid cells is described and the effector functions of these unique leukocyte subsets are discussed.

TL;DR: Findings indicate that IL‐4 plays an important role in the onset of DNFB‐induced CH in BALB/c mice, but not in C57BL/6 mice.

TL;DR: The Vα14 NKT cell–deficient mice could no longer mediate the interleukin-12 (IL-12)–induced rejection of tumors, and they mediated their cytotoxicity by an NK-like effector mechanism after activation with IL-12.

TL;DR: This perspective article seeks to clarify which cells fall under the NKT-cell umbrella, and which might be best considered as separate.

TL;DR: Pulmonary Vα14i NKT cells crucially regulate the development of asthma and Th2-biased respiratory immunity against nominal exogenous antigens.

TL;DR: In this paper, the authors investigated the mechanisms for down-regulation of cytotoxic T lymphocyte-mediated tumor immunosurveillance using a mouse model in which tumors show a growth-regression-recurrence pattern.