Intraoperative recurrence of probable allergic reaction to remifentanil. Case report
TL;DR: Any medication or potential allergen to which a patient is exposed during the perioperative period may cause anaphylaxis; the usual culprits are neuromuscular blocking agents (NMBA).
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About: This article is published in Colombian Journal of Anesthesiology. The article was published on 01 Jan 2017. and is currently open access. The article focuses on the topics: Remifentanil & Anaphylaxis.
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Citations
Toxicities of opioid analgesics: respiratory depression, histamine release, hemodynamic changes, hypersensitivity, serotonin toxicity.
TL;DR: In 2016, the FDA issued a Drug Safety Communication concerning the association of opioids with serotonin syndrome, a toxicity associated with raised intra-synaptic concentrations of serotonin in the CNS, inhibition of serotonin reuptake, and activation of 5-HT receptors as discussed by the authors.
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Two probable anaphylactic events during consecutive cranial surgeries: case report
Rafael Ramirez-Gonzales,Román Augusto Del-Castillo-Gervasi,Carlos Javier Shiraishi-Zapata,John N Laurencio-Ambrosio +3 more
TL;DR: A case of a patient that sustained 2 probable anaphylactic reactions during consecutive cranial surgeries under general anesthesia; the causal agent could not be confirmed.
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References
Incidence and severity of anaphylactoid reactions to colloid volume substitutes
Johannes Ring,Konrad Messmer +1 more
TL;DR: All available colloid volume substitutes carry the risk of anaphylactoid reactions, but the frequency of severe reactions was low for plasma-protein solutions, hydroxyethyl starch, 0-008% for dextran, and 0-038% for gelatin solutions.
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Incidence and severity of anaphylactoid reactions to colloid volume substitutes
Johannes Ring,Konrad Messmer +1 more
TL;DR: In a multicentre prospective trial, 69 cases of anaphylactoid reactions have been observed among 200 906 infusions of colloid volume substitutes as mentioned in this paper, and the frequency of severe reactions (shock, cardiac and/or respiratory arrest) was 0-003% for plasma-protein solutions, 0-006% for hydroxyethyl starch, 0 -008% for dextran, and 0-038% for gelatin solutions.
748
Suspected Anaphylactic Reactions Associated with Anaesthesia
Nigel J.N. Harper,T Dixon,P Dugué,D M Edgar,A Fay,H C Gooi,R Herriot,P Hopkins,J M Hunter,R Mirakian,Richard S. H. Pumphrey,S L Seneviratne,Andrew F. Walls,P Williams,J.A.W. Wildsmith,P Wood.,A S Nasser,R K Powell,R Mirakhur,Jasmeet Soar +19 more
TL;DR: This guidance recommends that all Departments of Anaesthesia should identify a Consultant Anaesthetist who is Clinical Lead for anaesthetic anaphylaxis, which is needed to recognise possible non-allergic causes for the ‘reaction’.
The incidence and clinical features of anaphylactic reactions during anaesthesia in Australia
M. McD. Fisher,Brian A. Baldo +1 more
TL;DR: L'origine anaphylactique de l'accident grave a ete prouvee chez 443 d'entre eux ; pour la majorite de ceux-ci (263), un curarisant a ee responsable du choc.
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Allergic reactions to drugs and biologic agents.
TL;DR: It is often difficult to tell if a condition represents a primary hypersensitivity reaction or a response to another form of organ damage, so an understanding of the distinction is important.
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