Patent
Intraocular drug delivery device and associated methods
Balamurali K. Ambati,Bruce K. Gale +1 more
- 12 May 2009
49
TL;DR: In this article, the authors present devices, systems, and methods for delivery of an active agent into the eye of a subject, where the active agent is disposed in an annular housing and the annular house is configured to fit inside of a lens capsule and at least partially encircling a line of sight of an intraocular lens within the lens capsule.
read more
Abstract: The present invention provides devices, systems, and methods for delivery of an active agent into the eye of a subject. In one aspect, for example, an ocular active agent delivery device (10) can include an active agent reservoir (14) disposed in an annular housing (12), the annular housing (12) being configured to fit inside of a lens capsule and at least partially encircling a line of sight of an intraocular lens within the lens capsule. The device (10) can further include a semipermeable membrane (16) operatively coupled to the active agent reservoir (14), where the semipermeable membrane (16) is configured to allow diffusion of an active agent from the active agent reservoir (14). Additionally, a valve (18) can be operatively coupled to the active agent reservoir (14), where the valve (18) is configured to allow filling of the active agent reservoir (14) with an active agent.
read more
Chat with Paper
AI Agents for this Paper
Find similar papers on Google Scholar, PubMed and Arxiv
Write a critical review of this paper
Analyze citations of this paper to find unaddressed research gaps
Citations
Patent
Posterior segment drug delivery
Yair Alster,Eugene de Juan,Cary J. Reich,Stephen Boyd,David Sierra,Jose D. Alejandro,K. Angela Macfarlane,Douglas Sutton +7 more
- 29 Jan 2010
TL;DR: In this article, the authors describe a therapeutic device to release a therapeutic agent consisting of a porous structure coupled to a container comprising a reservoir, which contains a volume sized to release therapeutic amounts of the therapeutic agent for an extended time when coupled to the porous structure and implanted in the patient.
115
Patent
Drug eluting ocular implant
David Haffner,Kenneth M. Curry,Harold A. Heitzmann,David Applegate +3 more
- 18 May 2010
TL;DR: In this paper, drug delivery devices and methods for the treatment of ocular disorders requiring targeted and controlled administration of a drug to an interior portion of the eye for reduction or prevention of symptoms of the disorder are presented.
71
Patent
Ocular implant delivery system and method
Duane Frion,Rebecca Mccarville,Andrew T. Schieber,Nathaniel Zenz-Olson,Diane M. Feehan,Edward Matthees,Charles L. Euteneuer +6 more
- 12 Nov 2008
TL;DR: In this article, a method of inserting an ocular implant into a patient's eye, mounted on a carrier, the method comprising: inserting a cannula into an anterior chamber of the eye; moving a distal exit port of the cannula, into communication with Schlemm's canal; and advancing the ocular implanted and carrier through an exit port, into the canal.
65
Patent
Methods and apparatus for treating glaucoma
Charles L. Euteneuer,Thomas R. Hektner,Andrew T. Schieber,John L. Wardle +3 more
- 05 Mar 2009
TL;DR: An ocular implant for treating glaucoma is provided in this article, which may include any number of features, such as bias to assume a predetermined shape to aid in placement within the eye.
65
Patent
Ocular Implants and Methods for Delivering Ocular Implants Into the Eye
John L. Wardle,Andrew T. Schieber,Kenneth M. Galt +2 more
- 09 Jul 2010
TL;DR: In this paper, an ocular implant is configured such that the distal portion of the implant assumes an orientation in which the channel opening is adjacent a major side of Schlemm's canal.
56
References
Patent
Biodegradable controlled release flash flow melt-spun delivery system
Richard C. Fuisz
- 03 Jun 1992
TL;DR: In this paper, the authors describe a system using melt-spun biodegradable polymers as carriers for bio-effecting agents such as pharmaceutical actives such as actives.
227
Patent
"Spare parts" for use in ophthalmic surgical procedures
David W. Langerman
- 15 Mar 1996
TL;DR: For use in ophthalmic surgery, the surgeon has available a supply of "spare parts" which are artificial members, possibly simulating different components of the eye, that are suited, depending on their structural forms and shapes, for surgical implantation in the eye as and/or in connection with repair and reinforcement and or replacement structures for damaged or diseased eye components.
226
Patent
Tack for intraocular drug delivery and method for inserting and removing same
Alan L. Weiner,Kevin Sinnett,Sterling Johnson +2 more
- 24 Apr 1995
TL;DR: In this paper, a tack for intraocular drug delivery and a method for insertion and removal of an intraocular device for sustained release of a drug is described, which consists of a post, an anchoring region and a head.
222
Patent
Bioerodible ocular device
Takeru Higuchi,Anwar Hussain,John W. Shell +2 more
- 31 Jul 1975
TL;DR: An ocular insert for the continuous controlled administration of a predetermined therapeutically effective dosage of drug to the eye over a prolonged period of time was proposed in this article. But the insert bioerodes in the environment of the eye concurrently with dispensing or at a point in time after the dispensing of the prescribed amount of drug.
211
Patent
Method of implanting intraocular and intraorbital implantable devices for the controlled release of pharmacological agents
Jean-Marie A. Parel,Richard K. Parrish,Lourdes Portugal,Karl R. Olsen +3 more
- 06 Feb 1991
TL;DR: A series of implants for intraocular and/or intraorbital use are provided which permit the controlled release of pharmacological agents as mentioned in this paper, which are substantial C-shaped rings and are insertable through incisions made in the eye wall or are sutured around the globe of the eye.
204