Intermittent fasting vs daily calorie restriction for type 2 diabetes prevention: a review of human findings

TL;DR: The regulation of SIRT1 by strigolactone GR24 and the activation of AMPK by pinosylvin may offer novel therapeutic approaches in the treatment of insulin resistance in skeletal muscle.

TL;DR: Recommending diets based on intermittent fasting in humans is based on the promising results found in animal models where an improvement in β cell function has been recorded, and also provides important safety advice in order to avoid adverse effects.

TL;DR: In this article , a review of the current knowledge on how time-restricted feeding (TRF) and continuous CR affect gut peptides that influence satiety is presented. But unlike CR, TRF did not appear to robustly increase ghrelin, suggesting different influences on appetite.

TL;DR: Patients with BRAF-mutated metastatic melanoma benefit greatly from the novel BRAF inhibitor dabrafenib and the checkpoint inhibitor ipilimumab, recently listed under the Australian Pharmaceutical Benefits Scheme (PBS).

TL;DR: Diet and/or exercise interventions led to a significant decrease in the incidence of diabetes over a 6-year period among those with IGT, and thereby reduce the overall incidence of diabetic complications.

TL;DR: The relations between change in adult weight and the risk for noninsulin-dependent diabetes mellitus among women during 14 years of follow-up were quantified.

TL;DR: In this article, the authors explored the contribution of changes in weight, diet, and physical activity on the risk of developing diabetes among ILS participants, and found that weight loss was the dominant predictor of reduced diabetes incidence (hazard ratio per 5-kg weight loss 0.42 [95% CI 0.35-0.51]; P < 0.0001).

TL;DR: It is concluded that long-term intervention in the form of diet and physical exercise is feasible even on a large scale, and that substantial metabolic improvement can be achieved which may contribute to prevent or postpone manifest diabetes.