Interlink between the gut microbiota and inflammation in the context of oxidative stress in Alzheimer’s disease progression
Tushar Kanti Das,Bhanu P. Ganesh +1 more
TL;DR: In this article , the authors summarized the current information of the fundamental connections between oxidative stress, inflammation, and gut dysbiosis in Alzheimer's disease and provided insights for novel preventative and therapeutic approaches in AD.
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Abstract: ABSTRACT The microbiota-gut-brain axis is an important pathway of communication and may dynamically contribute to Alzheimer’s disease (AD) pathogenesis. Pathological commensal gut microbiota alterations, termed as dysbiosis, can influence intestinal permeability and break the blood–brain barrier which may trigger AD pathogenesis via redox signaling, neuronal, immune, and metabolic pathways. Dysbiosis increases the oxidative stress. Oxidants affect the innate immune system through recognizing microbial-derived pathogens by Toll-like receptors and initiating the inflammatory process. Most of the gut microbiome research work highlights the relationship between the gut microbiota and AD, but the contributory connection between precise bacteria and brain dysfunction in AD pathology cannot be fully demonstrated. Here, we summarize the current information of the fundamental connections between oxidative stress, inflammation, and gut dysbiosis in AD. This review emphasizes on the involvement of gut microbiota in the regulation of oxidative stress, inflammation, immune responses including central and peripheral cross-talk. It provides insights for novel preventative and therapeutic approaches in AD.
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Polysaccharides extracted from common buckwheat (Fagopyrum esculentum) attenuate cognitive impairment via suppressing RAGE/p38/NF-κB signaling and dysbiosis in AlCl3-treated rats
Yuchen Liu,Shengyi Chen,Yingying Chen,Hsin Hsin Chang,I‐Chen Chiang,Gow‐Chin Yen +5 more
TL;DR: Overall, FEP mitigated oxidative stress, RAGE/p38/NF-κB-mediated neuroinflammation, and AD-associated proteins by upregulating autophagy and SCFA levels, which led to the amelioration of cognitive impairment through microbiota-gut-brain communication in AlCl3-treated rats.
Gut Microbiota Modulation with Probiotics: Potential Therapeutic Avenues for Alzheimer’s and Parkinson’s Diseases
Bosco Chambilo,Tejaswi Dhiver,Khemraj Sahu,Ravi Parashar,Ravi Parashar +4 more
Abstract: A BSTRACT Probiotics are live microorganisms that provide health benefits by regulating gut microbiota and maintaining overall physiological functions when consumed in adequate amounts. Neurodegenerative disorders are characterized by progressive neuronal loss and declining cognitive or motor abilities. Growing evidence highlights a strong link between gut health and brain function. Probiotics may influence neurodegeneration through multiple mechanisms, including reducing oxidative stress, modulating inflammation, and regulating the gut-brain axis. This article examines the therapeutic potential of probiotics in neurodegenerative diseases, particularly Alzheimer’s disease and Parkinson’s disease. Preclinical studies demonstrate promising benefits, but large-scale, well-controlled clinical trials are still needed to confirm their efficacy. Immune regulation and gut-brain communication remain central to their therapeutic effects. Overall, probiotics represent a novel and promising strategy for managing neurodegeneration, though significant research gaps remain.
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