Journal Article10.1182/BLOOD.V97.6.1525
Interleukin-7 restores immunity in athymic T-cell-depleted hosts.
Terry J. Fry,Terry J. Fry,Barbara L. Christensen,Barbara L. Christensen,Kristin L. Komschlies,Kristin L. Komschlies,Ronald E. Gress,Ronald E. Gress,Crystal L. Mackall,Crystal L. Mackall +9 more
168
TL;DR: It is shown that immune competence for even stringent antigens such as HY can be restored in the absence of thymic function and IL-7 is identified as a potent modulator ofThymic-independent T-cell regeneration.
read more
About: This article is published in Blood. The article was published on 15 Mar 2001. The article focuses on the topics: T cell & Immune system.
read more
Chat with Paper
AI Agents for this Paper
Find similar papers on Google Scholar, PubMed and Arxiv
Write a critical review of this paper
Analyze citations of this paper to find unaddressed research gaps
Citations
The Many Faces of IL-7: From Lymphopoiesis to Peripheral T Cell Maintenance
Terry J. Fry,Crystal L. Mackall +1 more
TL;DR: IL-7 plays critical and nonredundant roles in both T cell lymphopoiesis and in maintaining and restoring peripheral T cell homeostasis.
612
Harnessing the biology of IL-7 for therapeutic application
TL;DR: The biology of IL-7 and the results of its clinical use that are available so far are summarized to provide a perspective on the opportunities for clinical application of this cytokine.
Interleukin-7: from bench to clinic.
Terry J. Fry,Crystal L. Mackall +1 more
TL;DR: The complete set of physiologic roles for this cytokine, especially those involving lymphocyte homeostasis, have only recently been elucidated, after the initial descriptions of effects on B-cell precursors.
532
Thymic involution and immune reconstitution
Heather E. Lynch,Gabrielle L. Goldberg,Ann P. Chidgey,Marcel R.M. van den Brink,Richard L. Boyd,Gregory D. Sempowski +5 more
TL;DR: Progress is presented on the exploitation of thymosuppressive and thymostimulatory pathways using factors such as keratinocyte growth factor, interleukin 7 or sex steroid ablation for therapeutic thymus restoration and peripheral immune reconstitution in adults.
488
T cell immune reconstitution following lymphodepletion.
TL;DR: Insight has permitted the manipulation of the immune system to maximize anti-tumor immunity through lymphopenia and led to an appreciation of mechanisms that underlie graft versus host disease.
348
References
Recombinant human IL-7 administration in mice affects colony-forming units-spleen and lymphoid precursor cell localization and accelerates engraftment of bone marrow transplants
Otto C. Boerman,Theresa A. Gregorio,Krzysztof J. Grzegorzewski,Connie R. Faltynek,James J. Kenny,Robert H. Wiltrout,Kristin L. Komschlies +6 more
TL;DR: Investigation of the effects of recombinant human interleukin‐7 on myeloid and lymphoid precursors and on bone marrow engraftment concluded that rhIL‐7 administration accelerates murine bone marrow cell engraftments and therefore may be useful in reducing theEngraftment time in bone marrow transplant patients.
32
•Journal Article
The origin of T cells in permanently reconstituted old athymic nude rats. Analysis using chromosome or allotype markers.
TL;DR: Only the donor-derived CD4+ cells in reconstituted nude rats displayed T-cell function; evidence to the contrary from karyotype analysis was flawed.
24
Interleukin-7-enhanced cytotoxic T lymphocyte activity after viral infection in marrow transplanted mice.
Ali Abdul-Hai,Arie Ben-Yehuda,Lola Weiss,G. Friedman,Zichria Zakay-Rones,S. Slavin,Reuven Or +6 more
TL;DR: In this paper, the authors showed that recombinant interleukin 7 (rIL-7) was associated with very low virus titers in the lung, involving T and B cell functions.
18
IL-7 promotes the survival and maturation but not differentiation of human post-thymic CD4+ T cells.
Jaythoon Hassan,Denis J. Reen +1 more
TL;DR: It is shown that as well as maintaining the naive T cell pool by enhancing cell survival and up‐regulating bcl‐2 expression, IL‐7 also functions as a maturation factor for post‐thymic naive T cells.
Differential Protective Action of Cytokines on Radiation-Induced Apoptosis of Peripheral Lymphocyte Subpopulations
Hidetoshi Seki,Kazuyuki Iwai,Hirokazu Kanegane,Akihiro Konno,Kunio Ohta,Kazuhide Ohta,Akihiro Yachie,Noboru Taniguchi,Toshio Miyawaki +8 more
TL;DR: The present study investigates the possible protective effects of various cytokines on radiation-induced apoptosis of apparently quiescent lymphocyte subpopulations and concludes that the protective effect by each cytokine might be partly attributed to enhancement of cellular expression of bcl-2 protein.