Journal Article10.1038/NRI.2016.95
Interleukin-33 in health and disease
948
TL;DR: The molecular and cellular characteristics of IL-33 are highlighted, together with its major role in health and disease and the potential therapeutic implications of these findings in humans are highlighted.
read more
Abstract: Interleukin-33 (IL-33) - a member of the IL-1 family - was originally described as an inducer of type 2 immune responses, activating T helper 2 (TH2) cells and mast cells. Now, evidence is accumulating that IL-33 also potently stimulates group 2 innate lymphoid cells (ILC2s), regulatory T (Treg) cells, TH1 cells, CD8+ T cells and natural killer (NK) cells. This pleiotropic nature is reflected in the role of IL-33 in tissue and metabolic homeostasis, infection, inflammation, cancer and diseases of the central nervous system. In this Review, we highlight the molecular and cellular characteristics of IL-33, together with its major role in health and disease and the potential therapeutic implications of these findings in humans.
read more
Chat with Paper
AI Agents for this Paper
Find similar papers on Google Scholar, PubMed and Arxiv
Write a critical review of this paper
Analyze citations of this paper to find unaddressed research gaps
Citations
NF-κB, inflammation, immunity and cancer: coming of age
Koji Taniguchi,Michael Karin +1 more
TL;DR: How the initial discovery of a role for NF-κB in linking inflammation and cancer led to an improved understanding of tumour-elicited inflammation and its effects on anticancer immunity is discussed.
2.2K
Overview of the IL-1 family in innate inflammation and acquired immunity.
TL;DR: Although the inflammatory properties of the IL‐1 family dominate in innate immunity, IL‐2 family member can play a role in acquired immunity and this overview is a condensed update.
1.4K
Interleukin-1 and Related Cytokines in the Regulation of Inflammation and Immunity.
TL;DR: The varied roles of IL-1 family members in immune homeostasis and their contribution to pathologies, including autoimmunity and auto-inflammation, dysmetabolism, cardiovascular disorders, and cancer are discussed.
829
Interleukin-33 (IL-33): A nuclear cytokine from the IL-1 family
TL;DR: 15 years of discoveries on IL‐33 protein are highlighted, including its molecular characteristics, nuclear localization, bioactive forms, cellular sources, mechanisms of release and regulation by proteases, and important roles in allergic, fibrotic, infectious, and chronic inflammatory diseases.
715
Mast cells as sources of cytokines, chemokines, and growth factors.
TL;DR: The evidence indicating which cytokines and growth factors can be produced by various populations of rodent and human mast cells in response to particular immune or non‐immune stimuli is summarized, and the proven or potential roles of such mast cell products in health and disease are commented on.
602
References
TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties.
Tim R. Mosmann,R L Coffman +1 more
TL;DR: Two types of cloned helper T cells are described, defined primarily by differences in the pattern of lymphokines ynthesized, and the different functions of the two types of cells and their lymphokine synthesis are discussed.
8.1K
IL-33, an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST2 and induces T helper type 2-associated cytokines
Jochen Schmitz,Alexander Owyang,Elizabeth R. Oldham,Yaoli Song,Erin Murphy,Terril K. McClanahan,Gerard Zurawski,Mehrdad M. Moshrefi,Jinzhong Qin,Xiaoxia Li,Daniel M. Gorman,J. Fernando Bazan,Robert A. Kastelein +12 more
TL;DR: A member of theIL-1 family, IL-33, which mediates its biological effects via IL-1 receptor ST 2, activates NF-kappaB and MAP kinases, and drives production of T(H)2-associated cytokines from in vitro polarized T( H)2 cells is reported.
3.7K
Innate lymphoid cells--a proposal for uniform nomenclature.
Hergen Spits,David Artis,Marco Colonna,Andreas Diefenbach,James P. Di Santo,Gérard Eberl,Shigeo Koyasu,Richard M. Locksley,Andrew N.J. McKenzie,Reina E. Mebius,Fiona Powrie,Eric Vivier,Eric Vivier +12 more
TL;DR: It is proposed that ILCs should be categorized into three groups based on the cytokines that they can produce and the transcription factors that regulate their development and function.
2.3K
Nuocytes represent a new innate effector leukocyte that mediates type-2 immunity
Daniel R. Neill,See Heng Wong,Agustin Bellosi,Robin J. Flynn,Maria Daly,Theresa K. A. Langford,Christine Bucks,Colleen M. Kane,Padraic G. Fallon,Richard Pannell,Helen E. Jolin,Andrew N.J. McKenzie +11 more
TL;DR: The identification and functional characterization of a new innate type-2 immune effector leukocyte that is named the nuocyte is presented, which represents a critically important innate effector cell in type- 2 immunity.
A large-scale, consortium-based genomewide association study of asthma.
Miriam F. Moffatt,Ivo Gut,Florence Demenais,David P. Strachan,Emmanuelle Bouzigon,Simon Heath,Erika von Mutius,Martin Farrall,Mark Lathrop,William O.C.M. Cookson +9 more
TL;DR: A few common alleles are associated with disease risk at all ages and suggest a role for communication of epithelial damage to the adaptive immune system and activation of airway inflammation in asthma.