Interleukin-1β maturation triggers its relocation to the plasma membrane for gasdermin-D-dependent and -independent secretion

TL;DR: The evidence that links pore-forming MACPF proteins to the control of growth factor and cytokine signalling is examined and it is attempted to reconcile how the MACPF domain may have been repurposed during evolution for developmental events rather than cell killing.

TL;DR: The bioscaffold acts as an inflammation trap and captures the proinflammatory cytokines secreted at the implant site and effectively modulates the local inflammation without the need for exogenous anti‐inflammatory agents and is very effective in inhibiting visceral adhesions formation and minimizing postsurgical complications.

TL;DR: The data demonstrate that antibody opsonisation of virions can activate macrophages in multiple ways and highlight the importance of cooperativity between multiple sensing networks to expose viruses to the inflammasome pathway, which is particularly important for how the innate immune system responds to infection in the presence of pre‐existing immunity.

TL;DR: Overall, the findings support that the bronchial epithelium may play a central role in the release of IL-1 family cytokines independently of NLRP3 in the lungs of smokers.

TL;DR: It is shown that gasdermin D is essential for caspase-11-dependent pyroptosis and interleukin-1β maturation and a key mediator of the host response against Gram-negative bacteria.

TL;DR: It is shown that GSDMD-NT oligomerizes in membranes to form pores that are visible by electron microscopy and kills cell-free bacteria in vitro and may have a direct bactericidal effect within the cytosol of host cells, but the importance of direct bacterial killing in controlling in vivo infection remains to be determined.

TL;DR: It is demonstrated that the liposome-leakage and pore-forming activities of the gasdermin-N domain are required for pyroptosis and provide insights into the roles of theGasdermin family in necrosis, immunity and diseases.

TL;DR: It is reported that gasdermin D (GSDMD) is another crucial component of inflammasomes and the presence of GSDMD protein in nigericin-induced NLRP3 inflammaomes is discovered by a quantitative mass spectrometry-based analysis.