Interleukin-17 Family Members and Inflammation
Jay K. Kolls,Anders Lindén +1 more
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TL;DR: Increasing evidence shows that IL-17 family members play an active role in inflammatory diseases, autoimmune diseases, and cancer, which places IL- 17 family members and their receptors as potential targets for future pharmacotherapy.
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About: This article is published in Immunity. The article was published on 01 Oct 2004. and is currently open access. The article focuses on the topics: IL 17 family & T-Cell Receptor Activation.
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A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17
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References
Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain
Daniel J. Cua,Jonathan P Sherlock,Yi Chen,Craig A. Murphy,Barbara L. Joyce,Brian W. P. Seymour,Linda Lucian,Wayne To,Sylvia Kwan,Tatyana Churakova,Sandra Zurawski,Maria T. Wiekowski,Sergio A. Lira,Sergio A. Lira,Daniel M. Gorman,Robert A. Kastelein,Jonathon D. Sedgwick +16 more
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Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12.
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Interleukin-23 Promotes a Distinct CD4 T Cell Activation State Characterized by the Production of Interleukin-17
TL;DR: Evidence is presented that murine IL-23, which is produced by activated dendritic cells, acts on memory T cells, resulting in elevated IL-17 secretion, which suggests that during a secondary immune response, IL- 23 can promote an activation state with features distinct from the well characterized Th1 and Th2 profiles.
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Gene-microarray analysis of multiple sclerosis lesions yields new targets validated in autoimmune encephalomyelitis
Christopher Lock,Guy Hermans,Rosetta Pedotti,Andrea Brendolan,Eric E. Schadt,Hideki Garren,Annette Langer-Gould,Samuel Strober,Barbara Cannella,John Allard,Klonowski Paul,Angela Austin,Nagin Lad,Naftali Kaminski,Stephen J. Galli,Jorge R. Oksenberg,Cedric S. Raine,Renu A. Heller,Lawrence Steinman +18 more
TL;DR: Large-scale analysis of transcripts in MS lesions elucidates new aspects of pathology and opens possibilities for therapy, and results in EAE corroborate the microarray studies on MS lesions.
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T cell interleukin-17 induces stromal cells to produce proinflammatory and hematopoietic cytokines.
François Fossiez,Odile Djossou,Pascale Chomarat,Leopoldo Flores-Romo,Smina Ait-Yahia,C Maat,Jean-Jacques Pin,Pierre Garrone,Eric Garcia,Sem Saeland,D Blanchard,Claude Gaillard,B Das Mahapatra,E Rouvier,Pierre Golstein,Jacques Banchereau,Serge Lebecque +16 more
TL;DR: Observations suggest that hIL-17 may constitute an early initiator of the T cell-dependent inflammmatory reaction; and an element of the cytokine network that bridges the immune system to hematopoiesis.
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