Journal Article10.1002/IJC.2910420514
Interleukin-1 and tumor necrosis factor production by tumor-associated mononuclear leukocytes and peripheral mononuclear leukocytes in cancer patients
James S. Economou,Steven D. Colquhoun,Timothy M. Anderson,William W. McBride,Sidney H. Golub,E. Carmack Holmes,Donald L. Morton +6 more
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TL;DR: The production of interleukin‐I and tumor necrosis factor (TNF) by tumor‐associated mononuclear leukocytes (TAML) and peripheral monon nuclear leukocyte (PBML) from 9 otherwise untreated patients with a variety of malignancies was assessed.
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Abstract: The production of interleukin-1 (IL-1) and tumor necrosis factor (TNF) by tumor-associated mononuclear leukocytes (TAML) and peripheral mononuclear leukocytes (PMBL) from 9 otherwise untreated patients with a variety of malignancies (lung, sarcoma, stomach, renal) was assessed. Cells were cultured for 24 hr in vitro in the presence or absence of lipopolysaccharide (LPS), and IL-1 and TNF levels were measured in culture supernatants. TNF production was comparable between TAMLs and PBMLs. However, a striking defect in IL-1 production by TAMLs was noted. There was no basal production of IL-1 and LPS-stimulated TAMLs produced only 1% the amount of IL-1 produced by LPS-stimulated PBMLs.
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Citations
Defective expression of the monocyte chemotactic protein-1 receptor CCR2 in macrophages associated with human ovarian carcinoma.
Antonio Sica,Alessandra Saccani,Barbara Bottazzi,Sergio Bernasconi,Paola Allavena,Brancatelli Gaetano,Francesca Fei,Graig LaRosa,Chris J. Scotton,Frances R. Balkwill,Alberto Mantovani,Alberto Mantovani +11 more
TL;DR: The finding of defective CCR2 expression in TAM, largely dependent on local TNF production, is consistent with previous in vitro data on down-regulation of chemokine receptors by proinflammatory molecules.
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IL-1 and IL-6 release by tumor-associated macrophages from human ovarian carcinoma.
Annalaura Erroi,Marina Sironi,Francesca Chiaffarino,Chen Zhen‐Guo,Manuela Mengozzi,Alberto Mantovani +5 more
TL;DR: TAM exhibit a dissociation in their capacity to release the functionally related monokines IL‐I and IL‐6, which may account for the elevation of liverderived acutephase proteins associated with malignancy.
104
•Journal Article
Analysis of interleukin 6 gene expression in cervical neoplasia using a quantitative polymerase chain reaction assay: evidence for enhanced interleukin 6 gene expression in invasive carcinoma
Eric Tartour,Alain Gey,Xavier Sastre-Garau,Christophe Pannetier,Véronique Mosseri,Philippe Kourilsky,Wolf H. Fridman +6 more
TL;DR: It is confirmed, in vivo, that IL-6 may play a role in the pathogenesis of carcinoma of the uterine cervix since its increased expression is associated with advanced neoplastic cervical lesions.
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Expression of mRNA for cytokines in tumor-infiltrating mononuclear cells in ovarian adenocarcinoma and invasive breast cancer.
Domenico Vitolo,Tony R. Zerbe,Anisa Kanbour,Carol Dahl,Ronald B. Herberman,Theresa L. Whiteside +5 more
TL;DR: Strong evidence for local activation of mononuclear cells in situ, exemplified by the expression of genes for cytokines, was obtained only in inflammatory lesions and in mucin‐producing breast carcinomas.
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Three-dimensional co-culture of human monocytes and macrophages with tumor cells: analysis of macrophage differentiation and activation
TL;DR: A 3‐dimensional interaction with tumor cells in vitro results in significant changes in the phenotype and function of the spheroid‐associated MO and MAC, indicating a disturbed MO to MAC maturation within tumor spheroids.
56
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