Interferon-gamma limits Th1 lymphocyte adhesion to inflamed endothelium: a nitric oxide regulatory feedback mechanism.
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TL;DR: In this paper, the effect of different cytokine microenvironments on the recruitment of Th1 and Th2 lymphocytes into tissue was examined via intravital microscopy of the cytokine-treated cremaster muscle.
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Abstract: CD4(+) T helper (Th1 and Th2) cell localization to a site of inflammation is important for the development, maintenance and regulation of an immune response. The factors that regulate Th1 and Th2 cell recruitment into tissue are not fully understood. The aim of the present study was to examine the effect of different cytokine microenvironments on the recruitment of Th1 and Th2 lymphocytes into tissue. Fluorescently labelled Th1 or Th2 lymphocyte-endothelial interactions were observed via intravital microscopy of the cytokine-treated cremaster muscle. Our results show that TNF-alpha alone is sufficient to maximally recruit Th1 cells. Surprisingly, treatment with TNF-alpha + IFN-gamma significantly decreased Th1 adhesion and emigration in comparison to TNF-alpha treatment alone. The decreased adhesion of Th1 cells in response to TNF-alpha + IFN-gamma reflected a decreased ability to bind to ICAM-1 and was iNOS-dependent. This phenomenon was not observed with Th2 cells. These results suggest that IFN-gamma may play a key immunomodulatory role in the recruitment of different T lymphocyte subsets. Indeed, blockade of IFN-gamma or iNOS function during the Th1-mediated contact hypersensitivity response resulted in an acceleration and exacerbation of the late-phase inflammatory response.
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The role of nitric oxide in the regulation of adaptive immune responses
S. Ibiza,J.M. Serrador +1 more
TL;DR: This review summarizes recent reports indicating an important role for NO in immune responses, focusing on the unresolved controversies concerning the production and function of NO in T lymphocytes.
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Nitric oxide controls proliferation of Leishmania major by inhibiting the recruitment of permissive host cells.
Pauline Formaglio,Mohamad Alabdullah,Anastasios Siokis,Juliane Handschuh,Ina Sauerland,Yan Fu,Anna Krone,Patricia Gintschel,Juliane Stettin,Sandrina Heyde,Juliane Mohr,Lars Philipsen,Anja Schröder,Philippe Robert,Gang Zhao,Sahamoddin Khailaie,Anne Dudeck,Jessica Bertrand,Gerald F. Späth,Sascha Kahlfuß,Philippe Bousso,Burkhart Schraven,Jochen Huehn,Sebastian Binder,Michael Meyer-Hermann,Andreas Müller +25 more
TL;DR: In this article, the authors show that low Leishmania major proliferation results not from direct NO impact on the pathogen but from reduced availability of proliferation-permissive host cells.
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Resolution of Cutaneous Leishmaniasis and Persistence of Leishmania major in the Absence of Arginase 1.
TL;DR: It is concluded that Arg1 expression by hematopoietic and endothelial cells is completely dispensable for clinical resolution of cutaneous leishmaniasis and for long-term persistence of L. major.
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A possible role to nitric oxide in the anti-inflammatory effects of amitriptyline.
TL;DR: The present results and the literature suggest that the anti-inflammatory effects of amitriptyline may be due to a decrease in NO production, and a decreases in IL-1β/TNF-α serum levels may also be implicated in the results observed.
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Induction of type 1 cytokines during neem leaf glycoprotein assisted carcinoembryonic antigen vaccination is associated with nitric oxide production.
Koustav Sarkar,Anamika Bose,Enamul Haque,Krishnendu Chakraborty,Tathagata Chakraborty,Shyamal Goswami,Diptendu Ghosh,Rathindranath Baral +7 more
TL;DR: Results clearly demonstrated the interdependence of two anti-tumor immune functions, namely, NO production and generation of type 1 immune response.
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