Interface-Driven Hybrid Materials Based on DNA-Functionalized Gold Nanoparticles
Biwu Liu,Juewen Liu +1 more
- 02 Oct 2019
- Vol. 1, Iss: 4, pp 825-847
169
TL;DR: This review focuses on the interfaces of DNA-functionalized gold nanoparticles including adsorption of thiol and DNA bases, colloidal stability of AuNPs, and related methods for preparing this conjugate.
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Abstract: DNA-functionalized gold nanoparticles (AuNPs) are popular hybrid materials with applications in directed assembly, biosensor development, and drug delivery. This system is particularly interesting due to the versatile optical and catalytic properties of AuNPs combined with the molecular recognition and programmable properties of DNA. Instead of emphasizing applications, this review focuses on the interfaces including adsorption of thiol and DNA bases, colloidal stability of AuNPs, and related methods for preparing this conjugate. The effects of salt, pH, proteins, and DNA base composition are discussed for controlling the conformation, density, and stability of DNA. Hybridization of DNA on AuNPs, DNA-directed growing of materials, and cellular uptake of this conjugate are discussed as examples to highlight the importance of the interfaces. Our understanding of these biointerfaces is still far from complete, and a few future research opportunities for engineering hybrid materials are described.
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References
A DNA-based Method for Rationally Assembling Nanoparticles Into Macroscopic Materials
TL;DR: A method for assembling colloidal gold nanoparticles rationally and reversibly into macroscopic aggregates by using the specificity of DNA interactions to direct the interactions between particles of different size and composition is described.
6.6K
Nanostructures in Biodiagnostics
Nathaniel L. Rosi,Chad A. Mirkin +1 more
TL;DR: Nathaniel L. Rosi focuses on the rational assembly of DNA-modified nanostructures into larger-scale materials and their roles in biodiagnostic screening for nucleic acids.
Selective Colorimetric Detection of Polynucleotides Based on the Distance-Dependent Optical Properties of Gold Nanoparticles
TL;DR: A highly selective, colorimetric polynucleotide detection method based on mercaptoalkyloligonucleotide-modified gold nanoparticle probes is reported, which can detect about 10 femtomoles of an oligonucleotide.
Gold nanoparticles in chemical and biological sensing.
TL;DR: The advent of AuNP as a sensory element provided a broad spectrum of innovative approaches for the detection of metal ions, small molecules, proteins, nucleic acids, malignant cells, etc. in a rapid and efficient manner.