Open AccessJournal Article
Interactome networks and human disease
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TL;DR: Why interactome networks are important to consider in biology, how they can be mapped and integrated with each other, what global properties are starting to emerge from interactome network models, and how these properties may relate to human disease are detailed.
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Abstract: Complex biological systems and cellular networks may underlie most genotype to phenotype relationships. Here, we review basic concepts in network biology, discussing different types of interactome networks and the insights that can come from analyzing them. We elaborate on why interactome networks are important to consider in biology, how they can be mapped and integrated with each other, what global properties are starting to emerge from interactome network models, and how these properties may relate to human disease.
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Network Organization of the Huntingtin Proteomic Interactome in Mammalian Brain
Dyna I. Shirasaki,Dyna I. Shirasaki,Erin R. Greiner,Erin R. Greiner,Ismael Al-Ramahi,Michelle Gray,Michelle Gray,Pinmanee Boontheung,Daniel H. Geschwind,Juan Botas,Giovanni Coppola,Steve Horvath,Joseph A. Loo,X. William Yang,X. William Yang +14 more
TL;DR: This study uses affinity-purification mass spectrometry to identify 747 candidate proteins that are complexed with Huntingtin (Htt) in distinct brain regions and ages in Huntington's disease (HD) and wild-type mouse brains and presents an approach for analyzing proteomic interactome data sets to build in vivo protein networks in complex tissues, such as the brain.
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