Journal Article10.1016/J.MICINF.2007.09.007
Interactions of pathogenic mycobacteria with host macrophages.
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TL;DR: This review will focus on the mechanisms used by the innate system of the host to detect and eliminate mycobacteria and the strategies used by M. tuberculosis to overcome host responses to establish a successful infection.
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About: This article is published in Microbes and Infection. The article was published on 01 Nov 2007. The article focuses on the topics: Tuberculosis & Mycobacterium tuberculosis.
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Citations
Thaxtomin biosynthesis: the path to plant pathogenicity in the genus Streptomyces.
Rosemary Loria,Dawn R. D. Bignell,Simon Moll,Jose C. Huguet-Tapia,Madhumita V. Joshi,Evan G. Johnson,Ryan F. Seipke,Donna M. Gibson +7 more
TL;DR: A second virulence gene in pathogenic Streptomyces species, nec1, encodes a novel secreted protein that may suppress plant defence responses, which likely explains the rapid emergence of new pathogenic species.
152
Increased frequency and cell death of CD16+ monocytes with Mycobacterium tuberculosis infection
TL;DR: Results show that tuberculosis patients have an augmented frequency of CD16(+) circulating monocytes which are more prone to produce TNF-α and to undergo cell death in response to M. tuberculosis infection.
125
Chemical synthesis of all phosphatidylinositol mannoside (PIM) glycans from Mycobacterium tuberculosis.
TL;DR: Robust synthetic protocols were developed for utilizing bicyclic and tricyclic orthoesters as well as mannosyl phosphates as glycosylating agents and each synthetic PIM was equipped with a thiol-linker for immobilization on surfaces and carrier proteins for biological and immunological studies.
111
Liposomes as drug delivery systems for the treatment of TB
TL;DR: The role of liposomes as nanodelivery systems for the treatment of TB allows an increase in the bioavailability of antibiotics, which may lead to a reduction in the time of treatment.
93
Insights into early mycobacterial pathogenesis from the zebrafish.
Robin Lesley,Lalita Ramakrishnan +1 more
TL;DR: The application of the zebrafish as a relatively new model host for the study of mycobacterial pathogenesis is discussed and new facets of the bacteria-host interactions in tuberculosis are uncovered.
92
References
Antimicrobial reactive oxygen and nitrogen species: concepts and controversies
TL;DR: A review of the regulation, generation and actions of these molecular mediators, as well as their roles in resisting infection, updates the reader on these concepts and the topical questions in the field.
1.6K
Transcriptional Adaptation of Mycobacterium tuberculosis within Macrophages Insights into the Phagosomal Environment
Dirk Schnappinger,Sabine Ehrt,Martin I. Voskuil,Yang Liu,Joseph A. Mangan,Irene M. Monahan,Gregory Dolganov,Brad Efron,Philip D. Butcher,Carl Nathan,Gary K. Schoolnik +10 more
TL;DR: The microbial transcriptome served as a bioprobe of the MTB phagosomal environment, showing it to be nitrosative, oxidative, functionally hypoxic, carbohydrate poor, and capable of perturbing the pathogen's cell envelope.
1.4K
Lack of acidification in Mycobacterium phagosomes produced by exclusion of the vesicular proton-ATPase
Sheila Sturgill-Koszycki,Paul H. Schlesinger,Prasanta Chakraborty,Pryce L. Haddix,Helen L. Collins,Agnes K. Fok,Richard D. Allen,Stephen L. Gluck,John E. Heuser,David G. Russell +9 more
TL;DR: Immunoelectron microscopy of infected macrophages and immunoblotting of isolated phagosomes showed that Mycobacterium vacuoles acquire the lysosomal membrane protein LAMP-1, but not the vesicular proton-adenosine triphosphatase (ATPase) responsible for phagosomal acidification.
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Tissue expression of human Toll-like receptors and differential regulation of Toll-like receptor mRNAs in leukocytes in response to microbes, their products, and cytokines.
Kol A. Zarember,Paul J. Godowski +1 more
TL;DR: Analysis of TLR expression in fractionated primary human leukocytes indicates that professional phagocytes express the greatest variety ofTLR mRNAs although several TLRs appear more restricted to B cells, suggesting additional roles for TLRs in adaptive immunity.
The WD repeat: a common architecture for diverse functions.
TL;DR: The solution of the three-dimensional structure of one WD- repeat protein and the assumption that the structure will be common to all members of this family has allowed subfamilies of WD-repeat proteins to be defined on the basis of probable surface similarity.
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