Interactions among Proteins Involved in Bud-site Selection and Bud-site Assembly in Saccharomyces cerevisiae
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TL;DR: Cdc24 enables the direct convergence of a Ras-likeprotein and a Rho-like protein with the SH3-domain-containing protein (Bem1) and that independent domains of Cdc24 are responsible for these different interactions.
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About: This article is published in Journal of Biological Chemistry. The article was published on 13 Jan 1995. and is currently open access. The article focuses on the topics: CDC42 & GTPase.
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Citations
Scaffold-mediated symmetry breaking by Cdc42p.
TL;DR: It is found that yeast Cdc42p was effectively polarized to a single random cortical site even in the combined absence of landmarks, microtubules and microfilaments, suggesting that assembly of a polarization site involves cycling of CDC42p between GTP- and GDP-bound forms, rather than functioning as a simple on/off switch.
301
Cell polarity in yeast.
TL;DR: Comparisons of the DNA sequences of genes involved in pathways that involve cell polarity have raised the possibility that these mechanisms are conserved in all eukaryotic cells.
254
Signaling from G protein-coupled receptors to c-Jun kinase involves beta gamma subunits of heterotrimeric G proteins acting on a Ras and Rac1-dependent pathway.
TL;DR: Transient expression in COS-7 cells of m1 and m2 muscarinic receptors (mAChRs) is used as a model system to study the signaling pathway linking G protein-coupled receptors to JNK, and it is shown that stimulation of either mus carinic receptor subtype leads to J NK activation.
252
Cell Polarity in Yeast.
TL;DR: Findings from budding and fission yeasts that reveal both a conserved core polarity circuit and several adaptations that each organism exploits to fulfill the needs of its lifestyle are reviewed.
References
The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors.
Anne J. Ridley,Alan Hall +1 more
TL;DR: Rho, a ras-related GTP-binding protein, rapidly stimulated stress fiber and focal adhesion formation when microinjected into serum-starved Swiss 3T3 cells, implying that rho is essential specifically for the coordinated assembly of focal adhesions and stress fibers induced by growth factors.
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The small GTP-binding protein rac regulates growth factor-induced membrane ruffling.
TL;DR: It is proposed that rac and rho are essential components of signal transduction pathways linking growth factors to the organization of polymerized actin and that growth factors act through rac to stimulate this rho-dependent response.
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The GTPase superfamily: a conserved switch for diverse cell functions
TL;DR: A molecular switch is a molecular switch whose "on" and "off" states are triggered by binding and hydrolysis of GTP as discussed by the authors. But the mechanism in myriad versions of the switch can be traced back to a single primordial protein.
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Proteins regulating Ras and its relatives.
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TL;DR: Many of these proteins are much larger and more complex than their targets, containing multiple domains capable of interacting with an intricate network of cellular enzymes and structures.
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Genetic Control of the Cell Division Cycle in Yeast
TL;DR: Two features which distinguish the cell cycle of Saccharomyces cerevisiae from most other eukaryotes are particularly useful for an analysis of the gene functions that control the cell division cycle.
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