Journal Article10.1002/ERV.2698
Interaction between polymorphisms of the oxytocinergic system genes and emotion perception in inpatients with anorexia nervosa.
Katarzyna Kucharska,Emilia Kot,Katarzyna Biernacka,Janusz Zimowski,Radosław Rogoza,Filip Rybakowski,Barbara Kostecka,Małgorzata Bednarska-Makaruk +7 more
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TL;DR: SNPs within genes related to OXT pathways may influence EP abilities and the leucyl/cystinylaminopeptidase rs4869317 SNP may be involved in the development of eating disorders psychopathology.
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Abstract: Objective The empirical literature describes the role of the oxytocinergic system in emotion perception (EP). Variants in the oxytocin (OXT) and oxytocin receptor genes have been associated with mental disorders, including anorexia nervosa (AN), that are characterized by difficulties in socioemotional functioning. Our study aimed to examine whether variability within the genes related to OXT pathways may play a role in facial EP in inpatients with AN. Method Single nucleotide polymorphisms (SNPs) of the following genes: oxytocin receptor (rs2254298, rs53576), OXT (rs6133010), OXT-arginine-vasopressin (rs2740204), CD38 (rs6449197, rs3796863), and human leucyl/cystinylaminopeptidase (rs4869317) were genotyped in 60 AN female inpatients and 60 healthy control females (HCs). Associations between genetic polymorphisms and EP as well as clinical symptoms were examined. Results The AN group showed decreased EP abilities compared with HCs. SNPs of rs2740204, rs6133010, and rs53576 were associated with differences in EP in women with AN and in HCs. The SNP of rs4869317 was associated with the level of eating disorders symptoms in HCs. Conclusions The OXT system may be involved in EP difficulties in AN. SNPs within genes related to OXT pathways may influence EP abilities. The leucyl/cystinylaminopeptidase rs4869317 SNP may be involved in the development of eating disorders psychopathology.
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Citations
Emotional regulation in eating disorders and gambling disorder: A transdiagnostic approach.
Lucero Munguía,Lucero Munguía,Susana Jiménez-Murcia,Susana Jiménez-Murcia,Susana Jiménez-Murcia,Roser Granero,Roser Granero,Isabel Baenas,Isabel Baenas,Zaida Agüera,Zaida Agüera,Isabel Sánchez,Isabel Sánchez,Ester Codina,Amparo del Pino-Gutiérrez,Amparo del Pino-Gutiérrez,Amparo del Pino-Gutiérrez,Guilia Testa,Guilia Testa,Janet Treasure,Fernando Fernández-Aranda,Fernando Fernández-Aranda,Fernando Fernández-Aranda +22 more
TL;DR: In this paper, the authors explored the existence of latent empirical groups between eating disorders and gambling disorders, based on emotion regulation difficulties and considering a set of indicators of personality traits, the severity of the disorder, and psychopathological distress.
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Dorsolateral prefrontal cortex and amygdala function during cognitive reappraisal predicts weight restoration and emotion regulation impairment in anorexia nervosa.
Trevor Steward,Trevor Steward,Trevor Steward,Ignacio Martínez-Zalacaín,Ignacio Martínez-Zalacaín,Gemma Mestre-Bach,Gemma Mestre-Bach,Gemma Mestre-Bach,Isabel Sánchez,Isabel Sánchez,Nadine Riesco,Nadine Riesco,Susana Jiménez-Murcia,Susana Jiménez-Murcia,Susana Jiménez-Murcia,Jose A Fernández-Formoso,Misericordia Veciana de las Heras,Nuria Custal,José M. Menchón,José M. Menchón,José M. Menchón,Carles Soriano-Mas,Carles Soriano-Mas,Carles Soriano-Mas,Fernando Fernández-Aranda,Fernando Fernández-Aranda,Fernando Fernández-Aranda +26 more
TL;DR: These findings indicate that individuals with AN present altered fronto-amygdalar response during cognitive reappraisal and that this response may serve as a predictor of response to treatment and be linked to clinical severity.
Potential shortcomings in current studies on the effect of intranasal oxytocin in Anorexia Nervosa and healthy controls - A systematic review and meta-analysis.
TL;DR: The current level of evidence is moderate showing no effect of intranasal oxytocin on AB or ER in AN, however, brain exposure may not have been sufficient which future studies with IN-OT need to ensure by considering dose and dose-to-task interval.
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Reduced emotion recognition from nonverbal cues in anorexia nervosa
Maximilian Blomberg,Katja Schlegel,Linda Stoll,Hagen Febry,Wally Wünsch-Leiteritz,Andreas Leiteritz,Timo Brockmeyer +6 more
TL;DR: In this article, the role of reduced emotion recognition ability (ERA) in the development and maintenance of anorexia nervosa (AN) was examined with an audio-visual measure that focuses strictly on multimodal nonverbal cues and allows to differentiate between ERA for different emotion categories.
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Low oxytocin levels are broadly associated with more pronounced psychopathology in anorexia nervosa with primarily restricting but not binge/purge eating behavior
Franziska Plessow,Francesca Galbiati,Kamryn T. Eddy,Madhusmita Misra,Karen K. Miller,Anne Klibanski,Anna Aulinas,Elizabeth A. Lawson +7 more
TL;DR: In this article , the authors investigated whether oxytocin levels are related to eating, affective, and socioemotional psychopathology in women with anorexia nervosa and separately with atypical AN/AtypAN-BP.
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TL;DR: DNA methylation of the OXTR site -934 was higher in schizophrenia spectrum than bipolar patients, and among patients, it was linked to behavioral deficits in social cognition and neuroanatomic structures known to support emotion processing only in schizophrenia Spectrum individuals.
Differential methylation of the oxytocin receptor gene in patients with anorexia nervosa: a pilot study.
TL;DR: Epigenetic misregulation of the OXTR gene may be implicated in anorexia nervosa, which may either be a mechanism linking environmental adversity to risk or may be a secondary consequence of the illness.
Elementary neurocognitive function, facial affect recognition and social-skills in schizophrenia
TL;DR: The results support the conclusion that facial affect recognition deficits are a crucial domain of impairment in schizophrenia that both contribute unique variance to social-skill deficits and may also mediate the relationship between some aspects of neurocognition and social- Skill.