Insulin stimulates testosterone biosynthesis by human thecal cells from women with polycystic ovary syndrome by activating its own receptor and using inositolglycan mediators as the signal transduction system.
TL;DR: It is suggested that inositolglycans serve as the signal transduction system for insulin's stimulation of human thecal testosterone biosynthesis.
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Abstract: To determine whether insulin stimulates human ovarian testosterone production in the polycystic ovary syndrome by activating its own receptor and using inositolglycan mediators as the signal transduction system, thecal cells from polycystic ovary syndrome women were isolated and cultured. Insulin and insulin-like growth factor I stimulated thecal testosterone biosynthesis. Antibody blockade of the insulin receptor abolished insulin's stimulatory action, whereas effective antibody blockade of the insulin-like growth factor I receptor did not alter insulin's stimulation of thecal testosterone biosynthesis. A chiro-inositol containing glycan (INS-2) increased thecal testosterone biosynthesis. Preincubation of cells with an antiinositolglycan antibody (A23939 or alpha IGP) abolished insulin's stimulatory effect, but not that of hCG. These findings suggest that inositolglycans serve as the signal transduction system for insulin's stimulation of human thecal testosterone biosynthesis.
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Citations
Insulin resistance, insulin sensitization and Insulin resistance, insulin sensitization and Insulin resistance, insulin sensitization and Insulin resistance, insulin sensitization and Insulin resistance, insulin sensitization and inflammation in polycystic ovarian syndrome inflammation in polycystic ovarian syndrome inflammation in polycystic ovarian syndrome inflammation in polycystic ovarian syndrome inflammation in polycystic ovarian syndrome
Vishal Bhatia,Gurkiran Dhindsa,Ruchi Bhatia,Dhindsa M,Bhatia +4 more
- 01 Jan 2004
TL;DR: In this article, it is estimated that 5-10% of women of reproductive age have polycystic ovarian syndrome (PCOS), while insulin resistance is not part of diagnostic criteria for PCOS, its importance in the pathogenesis of PCOS cannot be denied.
•Dissertation
Developmental origins of polycystic ovary syndrome : role of early adverse life events on adult health
Maria Manti
- 17 Mar 2020
TL;DR: It was shown that maternal androgen exposure can lead to transgenerational transmission of anxiety-like behavior in the third generation of female mice, but not the male offspring, without major impact of maternal obesity, and that this adverse cardiac phenotype is the result of an early cardiac reprogramming.
Changes in growth factors in polycystic ovarian syndrome
Elena Vasukova,Ekaterina Zaikova,O. V. Kalinina,I.V. Gorelova,E Vasilyeva,Maria A. Kokina,E. Grineva,Polina V. Popova +7 more
TL;DR: A case-control study carried out at the Almazov National Medical Research Centre (ANMRC) included 45 patients with polycystic ovary syndrome (PCOS) and 45 women with normal ovulation (22 women with a BMI < 25 kg/m2 and 23 women with an upper bound on the number of ovulation cycles as discussed by the authors ).
Polycystic Ovary Syndrome and Cardiometabolic Disease
Shuyi Wang,Amy M. Navratil,Jun Ren +2 more
- 01 Jan 2018
TL;DR: The metabolic features in PCOS focusing on obesity and type 2 diabetes, and their correlation with cardiometabolic disorders are discussed.
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E.M. Velazquez,Soaira Mendoza,Soaira Mendoza,Tracy Hamer,Tracy Hamer,Felix Sosa,Felix Sosa,Charles J. Glueck,Charles J. Glueck +8 more
TL;DR: Using polycystic ovary syndrome as a model of insulin resistance and hyperandrogenism, the effect of Metformin on lipoproteins, sex hormones, gonadotropins, and blood pressure in 26 women with PCOS was assessed.
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Stephen Franks
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TL;DR: It is of interest to realize that polycystic ovary syndrome has moved from a histology diagnosis of ovarian tissue to a heterogeneous clinical syndrome, to a reproductive endocrine abnormality with elevated serum luteinizing hormone and androgen levels, and to a metabolic disease characterized by hyperinsulinemia and dyslipidemia.
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Phosphatidylinositol-glycan anchors of membrane proteins: potential precursors of insulin mediators.
Guillermo Romero,Louis M. Luttrell,Alan D. Rogol,Konrad Zeller,Erik L. Hewlett,Joseph Larner +5 more
TL;DR: A new model of insulin action is suggested by showing that alkaline phosphatase release and dimyristoylglycerol production are independent processes and that the blockade of either event inhibits the production of insulin mediator.
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17α-Hydroxyprogesterone Responses to Leuprolide and Serum Androgens in Obese Women with and without Polycystic Ovary Syndrome after Dietary Weight Loss1
TL;DR: Serum insulin decreased in both PCOS and control groups and serum steroid concentrations and 17α-hydroxyprogesterone responses to leuprolide administration decreased, suggesting weight loss would decrease serum insulin and P450c17α activity in PCOS.
Polycystic ovarian disease: US features in 104 patients.
TL;DR: The most important feature of PCOD on US scans is the bilaterally increased numbers of developing follicles, usually more than five in each ovary.
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