Insulin stimulates testosterone biosynthesis by human thecal cells from women with polycystic ovary syndrome by activating its own receptor and using inositolglycan mediators as the signal transduction system.
TL;DR: It is suggested that inositolglycans serve as the signal transduction system for insulin's stimulation of human thecal testosterone biosynthesis.
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Abstract: To determine whether insulin stimulates human ovarian testosterone production in the polycystic ovary syndrome by activating its own receptor and using inositolglycan mediators as the signal transduction system, thecal cells from polycystic ovary syndrome women were isolated and cultured. Insulin and insulin-like growth factor I stimulated thecal testosterone biosynthesis. Antibody blockade of the insulin receptor abolished insulin's stimulatory action, whereas effective antibody blockade of the insulin-like growth factor I receptor did not alter insulin's stimulation of thecal testosterone biosynthesis. A chiro-inositol containing glycan (INS-2) increased thecal testosterone biosynthesis. Preincubation of cells with an antiinositolglycan antibody (A23939 or alpha IGP) abolished insulin's stimulatory effect, but not that of hCG. These findings suggest that inositolglycans serve as the signal transduction system for insulin's stimulation of human thecal testosterone biosynthesis.
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Citations
Endocrine and metabolic changes in women with polycystic ovaries and polycystic ovary syndrome
Riitta Koivunen
- 01 Jan 2001
TL;DR: The prevalence of the isolated ultrasonographic finding of polycystic ovaries (PCO) in the Finnish population and among women with a history of gestational diabetes (GDM) and changes in the present carbohydrate metabolism were investigated and the nature of the ovarian streoidogenic response of women with PCOS to exogenously administered human chorionic gonadotrophin, human menotrophins and follicle stimulating hormone was evaluated.
Increased insulin-like growth factor-1 in relation to cardiovascular function in polycystic ovary syndrome: friend or foe?
Namrata A. Desai,Snehal S. Patel +1 more
TL;DR: A current perspective on increased level of IGF-1 in PCOS is provided and also adds to the current controversy regarding the roles of IGF -1 in cardiovascular disease.
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Insulin Resistance and Polycystic ovary Syndrome: A Review
TL;DR: The role of insulin resistance in polycystic ovary syndrome is studied to understand whether Insulin Resistance is due to a defect in insulin action or a primary defect in β-cell function or decreased hepatic clearance of insulin, or a combination of all these factors.
Multi-omics analyses reveal the specific changes in gut metagenome and serum metabolome of patients with polycystic ovary syndrome
Zhan-Dong Yang,Huijiao Fu,Hui-Ting Su,Xuzi Cai,Yan Wang,Yanjun Hong,Jing Hu,Zhiyong Xie,Xuefeng Wang +8 more
TL;DR: The intestinal microbiome modifications by FMT were demonstrated to regulate PCOS phenotypes including metabolic variables and reproductive hormones, which may provide novel insights into discovering clinical diagnostic biomarkers and developing efficient therapeutic strategies for PCOS.
Effect of Glucocorticoid-Induced Insulin Resistance on Follicle Development and Ovulation 1
Katherine S. Hackbart,Pauline M. Cunha,R. K. Meyer,Milo C. Wiltbank +3 more
- 01 Jan 2013
TL;DR: In this article, the authors evaluated whether induction of insulin resistance, using dexamethasone (DEX), in a monovular animal model, the cow, could produce an ovarian phenotype similar to PCOS.
22
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Stephen Franks
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