Insulin stimulates testosterone biosynthesis by human thecal cells from women with polycystic ovary syndrome by activating its own receptor and using inositolglycan mediators as the signal transduction system.
TL;DR: It is suggested that inositolglycans serve as the signal transduction system for insulin's stimulation of human thecal testosterone biosynthesis.
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Abstract: To determine whether insulin stimulates human ovarian testosterone production in the polycystic ovary syndrome by activating its own receptor and using inositolglycan mediators as the signal transduction system, thecal cells from polycystic ovary syndrome women were isolated and cultured. Insulin and insulin-like growth factor I stimulated thecal testosterone biosynthesis. Antibody blockade of the insulin receptor abolished insulin's stimulatory action, whereas effective antibody blockade of the insulin-like growth factor I receptor did not alter insulin's stimulation of thecal testosterone biosynthesis. A chiro-inositol containing glycan (INS-2) increased thecal testosterone biosynthesis. Preincubation of cells with an antiinositolglycan antibody (A23939 or alpha IGP) abolished insulin's stimulatory effect, but not that of hCG. These findings suggest that inositolglycans serve as the signal transduction system for insulin's stimulation of human thecal testosterone biosynthesis.
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Is metformin a primary ovulatory agent in patients with polycystic ovary syndrome
TL;DR: There is strong evidence supporting the use of metformin as a primary ovulatory agent in women with PCOS and novel evidence suggests that insulin sensitizers may also play a role in reducing the risk of early pregnancy loss.
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Is There a Bidirectional Association between Polycystic Ovarian Syndrome and Periodontitis? A Systematic Review and Meta-analysis.
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Sustainability of 8% weight loss, reduction of insulin resistance, and amelioration of atherogenic-metabolic risk factors over 4 years by metformin-diet in women with polycystic ovary syndrome.
TL;DR: Metformin-diet in women with polycystic ovary syndrome effectively and safely reduces weight and LDL-C while raising HDL-C, and maintains these outcomes stable over 4 years.
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Effects of resveratrol on ovarian response to controlled ovarian hyperstimulation in ob/ob mice.
Estefanía Cabello,Pablo Garrido,Javier Morán,Carmen González del Rey,Plácido Llaneza,David Llaneza-Suarez,Ana Alonso,Celestino González +7 more
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E.M. Velazquez,Soaira Mendoza,Soaira Mendoza,Tracy Hamer,Tracy Hamer,Felix Sosa,Felix Sosa,Charles J. Glueck,Charles J. Glueck +8 more
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Stephen Franks
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TL;DR: It is of interest to realize that polycystic ovary syndrome has moved from a histology diagnosis of ovarian tissue to a heterogeneous clinical syndrome, to a reproductive endocrine abnormality with elevated serum luteinizing hormone and androgen levels, and to a metabolic disease characterized by hyperinsulinemia and dyslipidemia.
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Guillermo Romero,Louis M. Luttrell,Alan D. Rogol,Konrad Zeller,Erik L. Hewlett,Joseph Larner +5 more
TL;DR: A new model of insulin action is suggested by showing that alkaline phosphatase release and dimyristoylglycerol production are independent processes and that the blockade of either event inhibits the production of insulin mediator.
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17α-Hydroxyprogesterone Responses to Leuprolide and Serum Androgens in Obese Women with and without Polycystic Ovary Syndrome after Dietary Weight Loss1
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