Insulin Degrading Enzyme Is a Cellular Receptor Mediating Varicella-Zoster Virus Infection and Cell-to-Cell Spread
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TL;DR: These studies indicate that IDE is a cellular receptor for both cell-free and cell-associated VZV, which causes chickenpox and shingles.
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About: This article is published in Cell. The article was published on 20 Oct 2006. and is currently open access. The article focuses on the topics: Virus & Insulin-degrading enzyme.
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Citations
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Entry of herpesviruses into mammalian cells.
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Herpes virus fusion and entry: a story with many characters.
Roselyn J. Eisenberg,Doina Atanasiu,Tina M. Cairns,John R. Gallagher,Claude Krummenacher,Gary H. Cohen +5 more
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References
Herpes Simplex Virus gE/gI Expressed in Epithelial Cells Interferes with Cell-to-Cell Spread
TL;DR: It is shown that coexpression of a truncated form of gE and gI in a human keratinocyte line, HaCaT cells, decreased the spread of HSV between cells and appeared to be able to interact with cellular components of cell junctions, gE/gI receptors which can promote HSV cell-to-cell spread.
59
Soluble V Domain of Nectin-1/HveC Enables Entry of Herpes Simplex Virus Type 1 (HSV-1) into HSV-Resistant Cells by Binding to Viral Glycoprotein D
Heechung Kwon,Qing Bai,Hyunjung Baek,Kelly Felmet,Edward A. Burton,William F. Goins,Justus B. Cohen,Joseph C. Glorioso +7 more
TL;DR: The results demonstrate that the attachment function of gD is dispensable for entry provided that other means of attachment are available, such as gB and gC binding to cell surface glycosaminoglycans.
57
Novel, Soluble Isoform of the Herpes Simplex Virus (HSV) Receptor Nectin1 (or PRR1-HIgR-HveC) Modulates Positively and Negatively Susceptibility to HSV Infection
Marc Lopez,Francesca Cocchi,Elisa Avitabile,Annouck Leclerc,José Adélaïde,Gabriella Campadelli-Fiume,Patrice Dubreuil +6 more
TL;DR: The expression of nectin1γ cDNA in cells resistant to HSV infection and lacking HSV receptors enables HSV to enter the cell, which implies that it is present at the cell surface and has the potential both to mediate and to reduce HSV entry into cells.
48
Varicella-zoster virus glycoproteins E and I expressed in insect cells form a heterodimer that requires the N-terminal domain of glycoprotein I.
TL;DR: Findings indicate that the mature amino-terminus of gI is required for gE-gI complex formation by the external domains of VZV gE and gI.
44
Immunity in strain 2 guinea-pigs inoculated with vaccinia virus recombinants expressing varicella-zoster virus glycoproteins I, IV, V or the protein product of the immediate early gene 62.
Philip W. Lowry,Suzanne M. Solem,Brandi N. Watson,Celine M. Koropchak,Helen M. Thackray,Paul R. Kinchington,William T. Ruyechan,Paul Ling,John Hay,Ann M. Arvin +9 more
TL;DR: Variability in the capacity of herpesviral glycoproteins to elicit cell-mediated immunity in vivo is suggested in guinea-pigs and means that this major tegument protein of VZV could be a useful component for vaccine development.
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