Patent
Insulin analog formulations
Diane Lee Bakaysa,David N. Brems,Bruce H. Frank,Henry A. Havel,Allen H. Pekar +4 more
- 07 Sep 1995
168
TL;DR: In this paper, various parenteral pharmaceutical formulations, which comprise a mixture of a monomeric insulin analog and insulin-NPH, are described. But none of these formulations provide a rapid onset and a prolonged duration of action.
read more
Abstract: The present invention discloses various parenteral pharmaceutical formulations, which comprise a mixture of a monomeric insulin analog and insulin-NPH. The analog formulations provide a rapid onset and a prolonged duration of action.
read more
Chat with Paper
AI Agents for this Paper
Find similar papers on Google Scholar, PubMed and Arxiv
Write a critical review of this paper
Analyze citations of this paper to find unaddressed research gaps
Citations
Patent
Method for drug delivery to the pulmonary system
Solomon S. Steiner,Robert Feldstein,Huiling Lian,Christopher A. Rhodes,Gregory S. Shen +4 more
- 10 May 1996
TL;DR: In this article, a drug delivery system is based on the formation of diketopiperazine microparticles which are stable at a pH of 6.4 or less and unstable at pH of greater than 6.5.
178
Patent
Insulin delivery enhanced by coached breathing
Igor Gonda,Reid M. Rubsamen +1 more
- 18 Jun 2002
TL;DR: In this article, an aerosolized insulin formulation is delivered to a patient's lungs and the rate at which the insulin is absorbed into the blood is increased by the use of an inhale-exhale breathing maneuver.
171
Patent
Stable insulin formulations
Michael Rosario Defelippis,Michael Allen Dobbins,Bruce H. Frank,Shun Carmel Li,Dawn Marie Rebhun +4 more
- 12 Jun 1998
TL;DR: In this article, a monomeric insulin analog formulation stabilized against aggregation in which the buffering agent is either TRIS or arginine was presented, and the stable formulations of the present invention are useful for treating diabetes.
152
Patent
Acylated Insulin Analogs
Jeffrey Clayton Baker,Jose Michael Hanquier +1 more
- 14 Nov 1995
TL;DR: In this article, a monomeric insulin analog is presented, where the A chain is the naturally occurring sequence of the human insulin A chain and the B chain is modified at either position B28 and B29 or both.
137
Patent
Method of use of monomeric insulin as a means for improving the reproducibility of inhaled insulin
Igor Gonda,Reid M. Rubsamen,Stephen J. Farr +2 more
- 21 Jun 2001
TL;DR: In this article, the need for the delivery of insulin by injection can be reduced or eliminated by delivering an aerosolized monomeric insulin formulation, which is delivered to the patient from a hand-held, self-contained device.
134
References
Altering the association properties of insulin by amino acid replacement.
David N. Brems,L A Alter,M J Beckage,Ronald E. Chance,Richard D. DiMarchi,L K Green,Harlan Beall Long,Allen H. Pekar,James E. Shields,B. H. Frank +9 more
TL;DR: It is demonstrated that self-association of insulin can be drastically altered by substitution of one or two key amino acids, and the location of a prolyl residue at B28 is critical for high-affinity self-Association.
233
Patent
Insulin analogues and method of preparing the same
Jens Jorgen Veilgaard Brange,Norris Kjeld,Mogens Trier Hansen +2 more
- 29 Aug 1986
TL;DR: In this article, a rapid-acting human insulin analog is provided having less tendency to self-association into dimers, tetramers, hexamers, or polymers.
154
Patent
Monomeric insulin analog formulations
Michael R. De Felippis
- 01 Jun 1995
TL;DR: In this article, various parenteral pharmaceutical formulations, which comprise: a monomeric insulin analog, zinc, protamine, and phenolic derivative, have been described.
123
Patent
Human insulin analogues
Per Balschmidt,Jens Jorgen Veilgaard Brange +1 more
- 21 Dec 1989
TL;DR: In this article, a method for the preparation of such insulin analogues, insulin preparations containing the human insulin analogs of the invention and a method of treating Diabetes Mellitus using these human insulin analogue.
115