Inositol Trisphosphate Receptor Ca2+ Release Channels
TL;DR: Over the last decade, detailed quantitative studies of InsP3R channel function and its regulation by ligands and interacting proteins have provided new insights into a remarkable richness of channel regulation and of the structural aspects that underlie signal transduction and permeation.
read more
Abstract: The inositol 1,4,5-trisphosphate (InsP3) receptors (InsP3Rs) are a family of Ca2+ release channels localized predominately in the endoplasmic reticulum of all cell types. They function to release Ca2+ into the cytoplasm in response to InsP3 produced by diverse stimuli, generating complex local and global Ca2+ signals that regulate numerous cell physiological processes ranging from gene transcription to secretion to learning and memory. The InsP3R is a calcium-selective cation channel whose gating is regulated not only by InsP3, but by other ligands as well, in particular cytoplasmic Ca2+. Over the last decade, detailed quantitative studies of InsP3R channel function and its regulation by ligands and interacting proteins have provided new insights into a remarkable richness of channel regulation and of the structural aspects that underlie signal transduction and permeation. Here, we focus on these developments and review and synthesize the literature regarding the structure and single-channel properties of the InsP3R.
read more
Chat with Paper
AI Agents for this Paper
Find similar papers on Google Scholar, PubMed and Arxiv
Write a critical review of this paper
Analyze citations of this paper to find unaddressed research gaps
Citations
Type 1 Inositol (1,4,5)-Trisphosphate Receptor Activates Ryanodine Receptor 1 to Mediate Calcium Spark Signaling in Adult Mammalian Skeletal Muscle
Andoria Tjondrokoesoemo,Na Li,Na Li,Pei-Hui Lin,Pei-Hui Lin,Zui Pan,Zui Pan,Christopher Ferrante,Natalia Shirokova,Marco Brotto,Noah Weisleder,Noah Weisleder,Jianjie Ma,Jianjie Ma +13 more
TL;DR: This work shows that onset of these spatially confined Ca2+ sparks involves interaction between activation of IP3R and RyR near the sarcolemmal membrane, and indicates that membrane-delimited signaling involving cross-talk between IP3r1 and Ryr1 contributes to Ca2- spark activation in skeletal muscle.
31
Regulatory Mechanisms of Endoplasmic Reticulum Resident IP3 Receptors.
TL;DR: The regulatory mechanisms of inositol triphosphate receptors in calcium regulation and initiation of apoptosis during unfolded protein response are summarized.
31
Molecular determinants as therapeutic targets in cancer chemotherapy: An update.
TL;DR: This article focuses on the molecular determinants of oncogene-specific sub-organelles such as potential metabolites of mitochondria, endoplasmic reticulum, nucleus, nucleus (nucleolar phosphoprotein, nuclear pore complex, nuclear localization signal), lysosome (microenvironment, etc.) that might be exploited for the targeted delivery of anti-cancer drugs for therapeutic benefits.
31
Endogenous signalling pathways and caged-IP3 evoke Ca2+ puffs at the same abundant immobile intracellular sites
TL;DR: It is concluded that IP3-evoked Ca2+ puffs initiate at numerous immobile sites and the sites become more likely to fire as the IP3 concentration increases; there is no evidence that endogenous signalling pathways selectively deliver IP3 to specific sites.
•Journal Article
Molecular approaches for manipulating astrocytic signaling in vivo
TL;DR: Molecular tools that enable the selective manipulation of astrocytic signaling are discussed, including the tools to selectively activate and inactivateAstrocyte signaling in vivo, and a few tools in development are highlighted that present strong potential for advancing understanding of the role ofastrocytes in physiology, behavior, and pathology.
30
References
Calcium's Role in Mechanotransduction during Muscle Development
TL;DR: How diverse mechanical stimuli cause changes in calcium homeostasis by affecting membrane channels and the intracellular stores, which in turn regulate multiple pathways that impart these effects and control the fate of muscle tissue is discussed in detail.
On the Nature of Allosteric Transitions: A Plausible Model
TL;DR: "It is certain that all bodies whatsoever, though they have no sense, yet they have perception, and whether the body be alterant or alterec, evermore a perception precedeth operation; for else all bodies would be like one to another."
8.8K
Down-Regulation of Na+/K+ ATPase Activity by Human Parvovirus B19 Capsid Protein VP1
Ahmad Almilaji,Kalina Szteyn,Evelyn Fein,Tatsiana Pakladok,Carlos Munoz,Bernat Elvira,Syeda T. Towhid,Ioana Alesutan,Ekaterina Shumilina,C.-Thomas Bock,Reinhard Kandolf,Florian Lang +11 more
TL;DR: The B19V capsid protein VP1 is a powerful inhibitor of host cell Na+/K+ ATPase, an effect at least partially due to phospholipase A2 (PLA2) dependent formation of lysophosphatidylcholine.
The Structure of the Potassium Channel: Molecular Basis of K+ Conduction and Selectivity
Declan A. Doyle,João H.Morais Cabral,Richard A. Pfuetzner,Anling Kuo,Jacqueline M. Gulbis,Steven L. Cohen,Brian T. Chait,Roderick MacKinnon +7 more
TL;DR: The architecture of the pore establishes the physical principles underlying selective K+ conduction, which promotes ion conduction by exploiting electrostatic repulsive forces to overcome attractive forces between K+ ions and the selectivity filter.
Inositol trisphosphate and calcium signalling
TL;DR: Inositol trisphosphate is a second messenger that controls many cellular processes by generating internal calcium signals through receptors whose molecular and physiological properties closely resemble the calcium-mobilizing ryanodine receptors of muscle.
6.8K