Innovative strategies for intervertebral disc regenerative medicine: From cell therapies to multiscale delivery systems.

TL;DR: This work is the first to demonstrate that MSC-exos could modulate ER stress-induced apoptosis during AGEs-associated IVD degeneration, and highlight the therapeutic effects of exosomes in preventing IDD progression.

TL;DR: An overview of the current status of miRNA research in degenerative disc pathology is given, with a special focus on the involvement of miRNAs in ECM degradation, apoptosis, and inflammation, as well as mechanobiology.

TL;DR: The status of cell-based therapies for treating IVD degeneration and the current concept of endogenous repair are reviewed and emphasized and the challenges of the mobilization/differentiation of reparative progenitor cells through the delivery of biologics factors to stimulate IVD regeneration are highlighted.

TL;DR: In vitro models support a role for oxidative stress‐induced ferroptosis in the pathogenesis of IVDD and Knockdown and overexpression NCOA4 further prove TBHP may induce ferroPTosis of AFCs and NPCs in an autophagy‐dependent way.

TL;DR: This work provides direct evidence linking acute trauma, inflammatory factors, neo-innervation and potential degeneration and discogenic pain in vivo.

TL;DR: The development of prototype scaffolds with interconnective pores, carrying embedded microparticles that were loaded with insulin-like growth factor I (IGF-I), prepared by a porogen leaching protocol justify future investigations of the developed constructs for tissue engineering applications.

TL;DR: An improved understanding of the therapeutic effects of PRP-GHM treatment of degenerated IVDs is provided and no proliferating cells were found in the nucleus pulposus and inner annulus fibrosus in any groups, but the number of apoptotic cells after PRD treatment was significantly lower than that after other treatments.

TL;DR: The attitudes and beliefs of third year physiotherapy students not exposed to teaching are similar to those of community providers, and there is no difference between students with and without a history of LBP.