Innate Immunity in the CNS: Redefining the Relationship between the CNS and Its Environment
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TL;DR: The importance of the BBB as the first line of defense against brain infections and injuries of the CNS and the main molecular mechanisms involved in the control of the innate immune system ofThe CNS are discussed.
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About: This article is published in Neuron. The article was published on 24 Apr 2013. and is currently open access.
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TL;DR: Recent progress in understanding the biology of CNS pericytes is reviewed, revealing that pericyte deficiency in the CNS leads to BBB breakdown and brain hypoperfusion resulting in secondary neurodegenerative changes.
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