Journal Article10.1016/S0952-7915(97)80152-5
Innate immunity: impact on the adaptive immune response
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TL;DR: The intent in this review is to point out the similarities and differences in these two types of host response to infection, and to indicate the present level of understanding of how these can be integrated into a more complete description of the immune response.
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About: This article is published in Current Opinion in Immunology. The article was published on 01 Feb 1997. The article focuses on the topics: Acquired immune system & Innate immune system.
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References
CD14, a receptor for complexes of lipopolysaccharide (LPS) and LPS binding protein.
TL;DR: CD14, a differentiation antigen of monocytes, was found to bind complexes of LPS and LBP, and blockade of CD14 with monoclonal antibodies prevented synthesis of TNF-alpha by whole blood incubated with LPS.
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Cpg motifs in bacterial dna trigger direct b-cell activation
Arthur M. Krieg,Ae-Kyung Yi,Sara Matson,Thomas J. Waldschmidt,Gail A. Bishop,Gail A. Bishop,Rebecca M. Teasdale,Gary A. Koretzky,Dennis M. Klinman +8 more
TL;DR: The potent immune activation by CpG oligon nucleotides has impli-cations for the design and interpretation of studies using 'antisense' oligonucleotides and points to possible new applications as adjuvants.
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The instructive role of innate immunity in the acquired immune response.
TL;DR: Innate immunity has been considered only to provide rapid, incomplete antimicrobial host defense until the slower, more definitive acquired immune response develops but may have an additional role in determining which antigens the acquired immune system responds to and the nature of that response.
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