Innate immune modulation in EBV infection
TL;DR: Study of EBV-specific immune dysregulation is important for understanding EBV latency and oncogenesis, and will identify potential molecular targets for immunotherapeutic interventions.
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Abstract: Epstein-Barr Virus (EBV) belongs to the gammaherpesvirus family, members of which are oncogenic. Compared with other closely related herpesviruses, EBV has developed much more elaborate and sophisticated strategies for subverting host immune system, which may account for its high prevalence in immune competent hosts. Thus, study of EBV-specific immune dysregulation is important for understanding EBV latency and oncogenesis, and will identify potential molecular targets for immunotherapeutic interventions. Here I summarize the recent findings of individual EBV products in regulating host immune responses, with emphasis on the innate immune modulation.
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Citations
Gene/environment interactions in the pathogenesis of autoimmunity: new insights on the role of Toll-like receptors.
TL;DR: It is proposed that molecules involved in TLR pathway may represent the targets for novel therapeutic treatments in order to stop autoimmune processes.
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Increased expression of Toll-like receptors 7 and 9 in myasthenia gravis thymus characterized by active Epstein-Barr virus infection.
Paola Cavalcante,Barbara Galbardi,Sara Franzi,Stefania Marcuzzo,Claudia Barzago,Silvia Bonanno,Giorgia Camera,Lorenzo Maggi,Dimos Kapetis,Francesca Andreetta,Amelia Biasiucci,Teresio Motta,Carmelo Giardina,Carlo Antozzi,Fulvio Baggi,Renato Mantegazza,Pia Bernasconi +16 more
TL;DR: The overall findings indicate that EBV-driven TLR7- and TLR9-mediated innate immune responses may participate in the intra-thymic pathogenesis of MG and suggested thatTLR7/9 signaling may be involved in antiviral type I IFN production and long-term inflammation inEBV-infected MG thymuses.
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EBV Infection and Glucose Metabolism in Nasopharyngeal Carcinoma
TL;DR: A new perspective on the interplay between EBV infection and altered host metabolic pathways in NPC pathogenesis may offer novel and effective therapeutic strategies in the treatment of NPC and other EBV-associated malignancies.
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Oral ulceration associated with concurrent herpes simplex virus, cytomegalovirus, and Epstein-Barr virus infection in an immunocompromised patient
TL;DR: This is the first well-documented report of the definitive concomitant presence of HSV, CMV, and EBV in an immunocompromised patient and although the pathogenesis of coinfected ulcers remains unknown, a synergistic effect is possible.
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Multiple functions are mediated by the miRNAs of Epstein-Barr virus.
TL;DR: This work shall summarize these targets, the robustness of their identification, and examine how the regulation of these targets by EBV contributes to the successful infection of its host.
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TL;DR: The small RNA profile of cells infected by Epstein-Barr virus is recorded and it is shown that EBV expresses several microRNA (miRNA) genes, which are identified viral regulators of host and/or viral gene expression.
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