Inhaled Budesonide and Oral Dexamethasone Prevent Acute Mountain Sickness

TL;DR: These guidelines present the main prophylactic and therapeutic modalities for each disorder and provide recommendations about their role in disease management and suggest suggested approaches to prevention and management of each disorder that incorporate these recommendations.

TL;DR: Recent advances in the prevention and treatment of high altitude illness are reviewed, including new pharmacologic strategies for prophylaxis and revised treatment guidelines.

TL;DR: In this article, the authors summarized known mechanisms of HIF and NF-κB crosstalk and highlighted the physiological consequences that can arise from maladaptive hypoxia-induced inflammation.

TL;DR: A current understanding of the pathophysiology of these three forms of high altitude illness is provided and the current prevention and treatment measures of these diseases are elaborated.

TL;DR: The development and use of a new scale, the Epworth sleepiness scale (ESS), is described, which is a simple, self-administered questionnaire which is shown to provide a measurement of the subject's general level of daytime sleepiness.

TL;DR: Simulations with a pharmacokinetic/pharmacodynamic model using T helper cell counts and endogenous Cortisol as biomarkers for the effects of methylprednisolone suggest that the clinical efficacy of low-dose glucocorticoid regimens might be increased with twice-daily glucocORTicoid administration.